{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:16:18Z","timestamp":1789604178245,"version":"build-2803163510"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Since the development of a system for generating vesicular stomatitis virus (VSV) from plasmid DNAs, our laboratory has reported the expression of several different glycoproteins from recombinant VSVs. In one of these studies, high-level expression of an influenza virus hemagglutinin (HA) from a recombinant VSV-HA and efficient incorporation of the HA protein into the virions was reported (E. Kretzschmar, L. Buonocore, M. J. Schnell, and J. K. Rose, J. Virol. 71:5982\u20135989, 1997). We report here that VSV-HA is an effective intranasal vaccine vector that raises high levels of neutralizing antibody to influenza virus and completely protects mice from bronchial pneumonia caused by challenge with a lethal dose of influenza A virus. Additionally, these recombinant VSVs are less pathogenic than wild-type VSV (serotype Indiana). This vector-associated pathogenicity was subsequently eliminated through introduction of specific attenuating deletions. These live attenuated recombinant VSVs have great potential as vaccine vectors.<\/jats:p>","DOI":"10.1128\/jvi.72.6.4704-4711.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T18:13:30Z","timestamp":1577816010000},"page":"4704-4711","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":198,"title":["Vaccination with a Recombinant Vesicular Stomatitis Virus Expressing an Influenza Virus Hemagglutinin Provides Complete Protection from Influenza Virus Challenge"],"prefix":"10.1128","volume":"72","author":[{"given":"Anjeanette","family":"Roberts","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Kretzschmar","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archibald S.","family":"Perkins","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Forman","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Price","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Buonocore","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kawaoka","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->St. Jude Children\u2019s Research Hospital, Memphis, Tennessee 381012"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Rose","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(96)00022-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.9.6418-6424.1996"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a120721"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.8.4647-4653.1992"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb35946.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.6.3781-3787.1996"},{"key":"e_1_3_2_8_2","first-page":"1137","article-title":"Rhabdoviruses","volume":"1","author":"Dietzschold B.","year":"1996","unstructured":"Dietzschold B. 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