{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:44:57Z","timestamp":1775295897067,"version":"3.50.1"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n            is exposed to multiple antimicrobial compounds, including oxidative burst products and antibiotics. The various mechanisms and regulatory pathways governing susceptibility or resistance are complex and only superficially understood.\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Bacillus subtilis<\/jats:named-content>\n            recently has been shown to control disulfide stress responses by the thioredoxin-related YjbH protein, which binds to the transcriptional regulator Spx and controls its degradation via the proteasome-like ClpXP protease. We show that the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n            YjbH homolog has a role in susceptibility to the disulfide stress-inducing agent diamide that is similar to that in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">B. subtilis<\/jats:named-content>\n            , and we demonstrate that the four cysteine residues in YjbH are required for this activity. In addition, the inactivation of YjbH led to moderate resistance to oxacillin and other \u03b2-lactam antibiotics, and this phenotypic change was associated with higher penicillin-binding protein 4 levels and increased peptidoglycan cross-linking. Of note, the impact of YjbH on \u03b2-lactam susceptibility still was observed when the four cysteines of YjbH were mutated, indicating that the roles of YjbH in disulfide stress and \u03b2-lactam resistance rely on different types of interactions. These data suggest that the ClpXP adaptor YjbH has more target proteins than previously thought, and that oxidative burst and \u03b2-lactam resistance mechanisms of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n            are closely linked.\n          <\/jats:p>","DOI":"10.1128\/aac.00286-11","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T03:50:46Z","timestamp":1317095446000},"page":"5452-5458","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["New Role of the Disulfide Stress Effector YjbH in \u03b2-Lactam Susceptibility of Staphylococcus aureus"],"prefix":"10.1128","volume":"55","author":[{"given":"Nadine","family":"G\u00f6hring","sequence":"first","affiliation":[{"name":"Cellular and Molecular Microbiology, Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen, Elfriede-Aulhorn-Stra\u00dfe 6, 72076 T\u00fcbingen, Germany"}]},{"given":"Iris","family":"Fedtke","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Microbiology, Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen, Elfriede-Aulhorn-Stra\u00dfe 6, 72076 T\u00fcbingen, Germany"}]},{"given":"Guoqing","family":"Xia","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Microbiology, Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen, Elfriede-Aulhorn-Stra\u00dfe 6, 72076 T\u00fcbingen, Germany"}]},{"given":"Ana M.","family":"Jorge","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Cell Biology, Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica, Universidade Nova de Lisboa, Avenida da Rep\u00fablica, Apartado 127, 2781-901 Oeiras, Portugal"}]},{"given":"Mariana G.","family":"Pinho","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Cell Biology, Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica, Universidade Nova de Lisboa, Avenida da Rep\u00fablica, Apartado 127, 2781-901 Oeiras, Portugal"}]},{"given":"Ute","family":"Bertsche","sequence":"additional","affiliation":[{"name":"Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen, Auf der Morgenstelle 28, 72076 T\u00fcbingen, Germany"}]},{"given":"Andreas","family":"Peschel","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Microbiology, Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen, Elfriede-Aulhorn-Stra\u00dfe 6, 72076 T\u00fcbingen, Germany"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.11.6887-6891.2004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004304107"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00594-10"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04446.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-002-0436-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2008.00149.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.46.29053"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(92)90048-T"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb100269f"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"ChaibenjawongP.\nFosterS. J.. Desiccation tolerance in Staphylococcus aureus. Arch. Microbiol. 193:125\u2013135.","DOI":"10.1007\/s00203-010-0653-x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)49903-1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.10.5744"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2007.08.003"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi900437z"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.20.6294-6301.1997"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00395-07"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01289-08"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.9.3007"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04845.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.57.030502.090938"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.8.4902"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2185"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.9.2121"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05949.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.6.1967-1975.2003"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808203390806"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00049-08"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.8841"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.189"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00194-06"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.062268106"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191260798"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021577"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01782-06"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1086\/595740"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.2.326-334.2004"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1089\/152308602753625924"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00016-09"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.091208.073241"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00286-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00286-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:21:20Z","timestamp":1645485680000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00286-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1128\/AAC.00286-11"],"URL":"https:\/\/doi.org\/10.1128\/aac.00286-11","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"2011-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}