{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:29:04Z","timestamp":1772162944647,"version":"3.50.1"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This is the first case report of\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    -disseminated candidiasis describing the acquisition of echinocandin resistance following anidulafungin treatment. The initial isolates recovered were susceptible to echinocandins. However, during 27 days of anidulafungin treatment, two resistant strains were isolated (from the blood and peritoneal fluid). The resistant peritoneal fluid isolate exhibited a Ser663Pro mutation in position 1987 of\n                    <jats:italic>FKS2<\/jats:italic>\n                    HS1 (hot spot 1), whereas the resistant blood isolate displayed a phenylalanine deletion (Phe659).\n                  <\/jats:p>","DOI":"10.1128\/aac.00589-10","type":"journal-article","created":{"date-parts":[[2010,12,13]],"date-time":"2010-12-13T23:44:21Z","timestamp":1292283861000},"page":"1312-1314","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["<i>FKS2<\/i>\n                    Mutations Associated with Decreased Echinocandin Susceptibility of\n                    <i>Candida glabrata<\/i>\n                    following Anidulafungin Therapy"],"prefix":"10.1128","volume":"55","author":[{"given":"Sofia","family":"Costa-de-Oliveira","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Porto University, Alameda Prof. Hernani Monteiro, 4200 Porto, Portugal"},{"name":"Cardiovascular Research &amp; Development Unit, Faculty of Medicine, Porto University, Porto, Portugal"}]},{"given":"Isabel","family":"Marcos Miranda","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Porto University, Alameda Prof. Hernani Monteiro, 4200 Porto, Portugal"},{"name":"Cardiovascular Research &amp; Development Unit, Faculty of Medicine, Porto University, Porto, Portugal"}]},{"given":"Raquel M.","family":"Silva","sequence":"additional","affiliation":[{"name":"IPATIMUP\u2014Institute of Molecular Pathology and Immunology of Porto University, Rua Dr. Roberto Frias s\/n, 4200-465 Porto, Portugal"}]},{"given":"Ana","family":"Pinto e Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Porto University, Alameda Prof. Hernani Monteiro, 4200 Porto, Portugal"},{"name":"Cardiovascular Research &amp; Development Unit, Faculty of Medicine, Porto University, Porto, Portugal"}]},{"given":"Rita","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Porto University, Alameda Prof. Hernani Monteiro, 4200 Porto, Portugal"}]},{"given":"Anto\u0301nio","family":"Amorim","sequence":"additional","affiliation":[{"name":"IPATIMUP\u2014Institute of Molecular Pathology and Immunology of Porto University, Rua Dr. Roberto Frias s\/n, 4200-465 Porto, Portugal"},{"name":"Faculty of Sciences, Porto University, Pr. Gomes Teixeira, 4099-002 Porto, Portugal"}]},{"given":"Aca\u0301cio","family":"Gonc\u0327alves Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Porto University, Alameda Prof. Hernani Monteiro, 4200 Porto, Portugal"},{"name":"Cardiovascular Research &amp; Development Unit, Faculty of Medicine, Porto University, Porto, Portugal"},{"name":"Burn Unit, Department of Plastic and Reconstructive Surgery, Hospital S. Joa\u0303o, Porto, Portugal"}]},{"given":"Cida\u0301lia","family":"Pina-Vaz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Porto University, Alameda Prof. Hernani Monteiro, 4200 Porto, Portugal"},{"name":"Cardiovascular Research &amp; Development Unit, Faculty of Medicine, Porto University, Porto, Portugal"},{"name":"Department of Microbiology, Hospital S. 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