{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:40:36Z","timestamp":1776235236584,"version":"3.50.1"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Carbon monoxide (CO) is endogenously produced in the human body, mainly from the oxidation of heme catalyzed by heme oxygenase (HO) enzymes. The induction of HO and the consequent increase in CO production play important physiological roles in vasorelaxation and neurotransmission and in the immune system. The exogenous administration of CO gas and CO-releasing molecules (CO-RMs) has been shown to induce vascular effects and to alleviate hypoxia-reoxygenation injury of mammalian cells. In particular, due to its anti-inflammatory, antiapoptotic, and antiproliferative properties, CO inhibits ischemic-reperfusion injury and provides potent cytoprotective effects during organ and cell transplantation. In spite of these findings regarding the physiology and biology of mammals, nothing is known about the action of CO on bacteria. In the present work, we examined the effect of CO on bacterial cell proliferation. Cell growth experiments showed that CO caused the rapid death of the two pathogenic bacteria tested,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , particularly when delivered through organometallic CO-RMs. Of importance is the observation that the effectiveness of the CO-RMs was greater in near-anaerobic environments, as many pathogens are anaerobic organisms and pathogen colonization occurs in environments with low oxygen concentrations. Our results constitute the first evidence that CO can be utilized as an antimicrobial agent. We anticipate our results to be the starting point for the development of novel types of therapeutic drugs designed to combat antibiotic-resistant pathogens, which are widespread and presently a major public health concern.\n                  <\/jats:p>","DOI":"10.1128\/aac.00802-07","type":"journal-article","created":{"date-parts":[[2007,10,8]],"date-time":"2007-10-08T20:26:13Z","timestamp":1191875173000},"page":"4303-4307","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":174,"title":["Antimicrobial Action of Carbon Monoxide-Releasing Compounds"],"prefix":"10.1128","volume":"51","author":[{"given":"Li\u0301gia S.","family":"Nobre","sequence":"first","affiliation":[{"name":"Instituto de Tecnologia Qui\u0301mica e Biolo\u0301gica, Universidade Nova de Lisboa, Avenida da Repu\u0301blica (EAN), 2781-901 Oeiras"}]},{"given":"Joa\u0303o D.","family":"Seixas","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qui\u0301mica e Biolo\u0301gica, Universidade Nova de Lisboa, Avenida da Repu\u0301blica (EAN), 2781-901 Oeiras"},{"name":"Alfama, Lda., Taguspark, Nu\u0301cleo Central 267, 2740-122 Porto Salvo, Portugal"}]},{"given":"Carlos C.","family":"Roma\u0303o","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qui\u0301mica e Biolo\u0301gica, Universidade Nova de Lisboa, Avenida da Repu\u0301blica (EAN), 2781-901 Oeiras"},{"name":"Alfama, Lda., Taguspark, Nu\u0301cleo Central 267, 2740-122 Porto Salvo, Portugal"}]},{"given":"Li\u0301gia M.","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qui\u0301mica e Biolo\u0301gica, Universidade Nova de Lisboa, Avenida da Repu\u0301blica (EAN), 2781-901 Oeiras"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"61","year":"2006","unstructured":"Brooks, J. C., M. M. Brashears, M. F. Miller, A. R. Hoyle, J. D. Kellermeier, and J. M. Mehaffey. 2006. The spoilage characteristics of ground beef packaged in high-oxygen and low-oxygen modified atmosphere packages, p. 61-65. InProceedings of the Reciprocal Meat Conference. University of Illinois at Urbana-Champaign, Urbana-Champaign.","journal-title":"Proceedings of the Reciprocal Meat Conference."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic00208a022"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(03)00096-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1004"},{"key":"e_1_3_2_6_2","unstructured":"Herrmann W. A. and G. Brauer (ed.). 1997. Synthetic methods of organometallic and inorganic chemistry vol. 7. Georg Thieme Verlag Stuttgart Germany."},{"key":"e_1_3_2_7_2","first-page":"1500","volume":"15","year":"2007","unstructured":"Johnson, T. R., B. E. Mann, I. P. Teasdale, H. Adams, R. Foresti, C. J. Green, and R. Motterlini. 2007. Metal carbonyls as pharmaceuticals? [Ru(CO)3Cl(glycinate)], a CO-releasing molecule with an extensive aqueous solution chemistry. Dalton Trans.15:1500-1508.","journal-title":"Dalton Trans."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.7.2568"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706458"},{"key":"e_1_3_2_10_2","first-page":"E17","volume":"90","year":"2002","unstructured":"Motterlini, R., J. E. Clark, R. Foresti, P. Sarathchandra, B. E. Mann, and C. J. Green. 2002. Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ. Res.90:E17-E24.","journal-title":"Circ. Res."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.14.11.1305"},{"key":"e_1_3_2_12_2","first-page":"284","volume":"19","year":"2005","unstructured":"Motterlini, R., P. Sawle, J. Hammad, S. Bains, R. Alberto, R. Foresti, and C. J. Green. 2005. CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule. FASEB J.19:284-286.","journal-title":"FASEB J."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2003.01182.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00426.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/381972"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/152308602753666316"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2005"},{"key":"e_1_3_2_18_2","first-page":"RE6","volume":"2004","year":"2004","unstructured":"Ryter, S. W., D. Morse, and A. M. Choi. 2004. Carbon monoxide: to boldly go where NO has gone before. Sci. STKE2004:RE6.","journal-title":"Sci. STKE"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20005"},{"key":"e_1_3_2_20_2","first-page":"249","volume":"234","year":"2002","unstructured":"Ryter, S. W., L. E. Otterbein, D. Morse, and A. M. Choi. 2002. Heme oxygenase\/carbon monoxide signaling pathways: regulation and functional significance. Mol. Cell. Biochem.234-235:249-263.","journal-title":"Mol. Cell. Biochem."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(05)96031-X"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)40793-X"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.3"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00802-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00802-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:19:50Z","timestamp":1645453190000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00802-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1128\/AAC.00802-07"],"URL":"https:\/\/doi.org\/10.1128\/aac.00802-07","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718030782.793480290","asserted-by":"object"}]},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"2007-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}