{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T13:55:28Z","timestamp":1712670928159},"reference-count":38,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The new \u03b2-lactamase SHV-72 was isolated from clinical\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            INSRA1229, which exhibited the unusual association of resistance to the amoxicillin-clavulanic acid combination (MIC, 64 \u03bcg\/ml) and susceptibility to cephalosporins, aztreonam, and imipenem. SHV-72 (pI 7.6) harbored the three amino acid substitutions Ile8Phe, Ala146Val, and Lys234Arg. SHV-72 had high catalytic efficiency against penicillins (\n            <jats:italic>k<\/jats:italic>\n            <jats:sub>cat<\/jats:sub>\n            \/\n            <jats:italic>K<\/jats:italic>\n            <jats:sub>\n              <jats:italic>m<\/jats:italic>\n            <\/jats:sub>\n            , 35 to 287 \u03bcM\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7s\n            <jats:sup>\u22121<\/jats:sup>\n            ) and no activity against oxyimino \u03b2-lactams. The concentration of clavulanic acid necessary to inhibit the enzyme activity by 50% was 10-fold higher for SHV-72 than for SHV-1. Molecular-dynamics simulation suggested that the Lys234Arg substitution in SHV-72 stabilized an atypical conformation of the Ser130 side chain, which moved the O\u03b3 atom of Ser130 around 3.5 A\u030a away from the key O\u03b3 atom of the reactive serine (Ser70). This movement may therefore decrease the susceptibility to clavulanic acid by preventing cross-linking between Ser130 and Ser70.\n          <\/jats:p>","DOI":"10.1128\/aac.01381-07","type":"journal-article","created":{"date-parts":[[2008,3,4]],"date-time":"2008-03-04T01:53:06Z","timestamp":1204595586000},"page":"1806-1811","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["The Lys234Arg Substitution in the Enzyme SHV-72 Is a Determinant for Resistance to Clavulanic Acid Inhibition"],"prefix":"10.1128","volume":"52","author":[{"given":"Nuno","family":"Mendonc\u0327a","sequence":"first","affiliation":[{"name":"Antibiotic Resistance Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Vera","family":"Manageiro","sequence":"additional","affiliation":[{"name":"Antibiotic Resistance Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Fre\u0301de\u0301ric","family":"Robin","sequence":"additional","affiliation":[{"name":"University Clermont1, UFR Me\u0301decine, Laboratoire de bacte\u0301riologie, EA3844, Clermont-Ferrand F-63001, France"},{"name":"CHU Clermont-Ferrand, Centre de Biologie, Laboratoire de bacte\u0301riologie clinique, Clermont-Ferrand F-63003, France"}]},{"given":"M. Jose\u0301","family":"Salgado","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Hospital de Santa Maria, Lisbon, Portugal"}]},{"given":"Euge\u0301nia","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Antibiotic Resistance Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Manuela","family":"Canic\u0327a","sequence":"additional","affiliation":[{"name":"Antibiotic Resistance Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Richard","family":"Bonnet","sequence":"additional","affiliation":[{"name":"University Clermont1, UFR Me\u0301decine, Laboratoire de bacte\u0301riologie, EA3844, Clermont-Ferrand F-63001, France"},{"name":"CHU Clermont-Ferrand, Centre de Biologie, Laboratoire de bacte\u0301riologie clinique, Clermont-Ferrand F-63003, France"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1980.0049"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.9.2958-2961.2003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2006.05.005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.8.2269-2275.2001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.11.3061-3068.2000"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.933-951.2001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1211"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Recommandations. 2007","DOI":"10.1016\/S1773-035X(06)80601-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/43.4.447"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.9.2407-2413.2001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja042850a"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.731-738.2006"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4466-4469.2004"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306059200"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9621760"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi990136d"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(73)80154-1"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/02648725.1994.10647912"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.10.2709-2714.2000"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)47357-2"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi001653v"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s008940100045"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.4.557"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja016736t"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.06.023"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0259640"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.2.755-758.2003"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.4.838"},{"key":"e_1_3_2_33_2","first-page":"327","volume":"23","year":"1977","unstructured":"Ryckaert, J., G. 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