{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:54:22Z","timestamp":1762865662270},"reference-count":29,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We describe 66 ciprofloxacin-nonsusceptible\n            <jats:italic>Streptococcus pyogenes<\/jats:italic>\n            isolates recovered from colonized and infected children. The ParC S79A substitution was frequent and associated with the\n            <jats:italic>emm<\/jats:italic>\n            6\/sequence type 382 (\n            <jats:italic>emm<\/jats:italic>\n            6\/ST382) lineage. The ParC D83G substitution was detected in two isolates (\n            <jats:italic>emm<\/jats:italic>\n            5\/ST99 and\n            <jats:italic>emm<\/jats:italic>\n            28\/ST52 lineages). One isolate (\n            <jats:italic>emm<\/jats:italic>\n            89\/ST101) had no quinolone resistance-determining region codon substitutions or other resistance mechanisms. Five of 66 isolates were levofloxacin resistant. Although fluoroquinolones are not used in children, they may be putative disseminators of fluoroquinolone-nonsusceptible strains in the community.\n          <\/jats:p>","DOI":"10.1128\/aac.01536-09","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T03:55:06Z","timestamp":1269921306000},"page":"2677-2680","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Emergence of Ciprofloxacin-Nonsusceptible\n            <i>Streptococcus pyogenes<\/i>\n            Isolates from Healthy Children and Pediatric Patients in Portugal"],"prefix":"10.1128","volume":"54","author":[{"given":"Renato","family":"Pires","sequence":"first","affiliation":[{"name":"Centro de Recursos Microbiolo\u0301gicos (CREM), Departamento de Cie\u0302ncias da Vida, Faculdade de Cie\u0302ncias e Tecnologia (FCT), Universidade Nova de Lisboa, Caparica, Portugal"}]},{"given":"Carmen","family":"Ardanuy","sequence":"additional","affiliation":[{"name":"Microbiology Department, Institut d'Investigacio\u0301 Biome\u0300dica de Bellvitge, Hospital Universitari de Bellvitge, Barcelona, Spain"},{"name":"CIBER de Enfermedades Respirato\u0301rias, ISCIII, Madrid, Spain"}]},{"given":"Dora","family":"Rolo","sequence":"additional","affiliation":[{"name":"Centro de Recursos Microbiolo\u0301gicos (CREM), Departamento de Cie\u0302ncias da Vida, Faculdade de Cie\u0302ncias e Tecnologia (FCT), Universidade Nova de Lisboa, Caparica, Portugal"},{"name":"Microbiology Department, Institut d'Investigacio\u0301 Biome\u0300dica de Bellvitge, Hospital Universitari de Bellvitge, Barcelona, Spain"},{"name":"CIBER de Enfermedades Respirato\u0301rias, ISCIII, Madrid, Spain"}]},{"given":"Ana","family":"Morais","sequence":"additional","affiliation":[{"name":"Centro de Sau\u0301de de Oeiras, Oeiras, Portugal"}]},{"given":"Anto\u0301nio","family":"Brito-Avo\u0302","sequence":"additional","affiliation":[{"name":"Centro de Sau\u0301de de Oeiras, Oeiras, Portugal"}]},{"given":"Jose\u0301","family":"Gonc\u0327alo-Marques","sequence":"additional","affiliation":[{"name":"Hospital de Santa Maria, Lisbon, Portugal"}]},{"given":"Josefina","family":"Lin\u0303ares","sequence":"additional","affiliation":[{"name":"Microbiology Department, Institut d'Investigacio\u0301 Biome\u0300dica de Bellvitge, Hospital Universitari de Bellvitge, Barcelona, Spain"},{"name":"CIBER de Enfermedades Respirato\u0301rias, ISCIII, Madrid, Spain"}]},{"given":"Ilda","family":"Santos-Sanches","sequence":"additional","affiliation":[{"name":"Centro de Recursos Microbiolo\u0301gicos (CREM), Departamento de Cie\u0302ncias da Vida, Faculdade de Cie\u0302ncias e Tecnologia (FCT), Universidade Nova de Lisboa, Caparica, 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