{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T18:55:10Z","timestamp":1776797710031,"version":"3.51.2"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"FEDER, FCT","award":["SFRH\/BPD\/111148\/2015"],"award-info":[{"award-number":["SFRH\/BPD\/111148\/2015"]}]},{"DOI":"10.13039\/501100001871","name":"Ministry of Education and Science | Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["Ciencia 2008"],"award-info":[{"award-number":["Ciencia 2008"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,3,24]]},"abstract":"<jats:p>\n            Five\n            <jats:named-content content-type=\"genus-species\">Candida krusei<\/jats:named-content>\n            isolates (susceptible and resistant) recovered from the urine of a kidney transplant patient treated with voriconazole (VRC) 200\u2009mg twice daily for 20\u2009days were studied. Eight unrelated clinical isolates of\n            <jats:named-content content-type=\"genus-species\">C. krusei<\/jats:named-content>\n            were exposed\n            <jats:italic>in vitro<\/jats:italic>\n            to VRC 0.001\u2009\u03bcg\/ml for 30\u2009days. Development of VRC transient resistance occurred\n            <jats:italic>in vivo<\/jats:italic>\n            , and induction of permanent resistance occurred\n            <jats:italic>in vitro<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.01651-19","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T12:42:51Z","timestamp":1578919371000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Mechanisms of Acquired\n            <i>In Vivo<\/i>\n            and\n            <i>In Vitro<\/i>\n            Resistance to Voriconazole by Candida krusei following Exposure to Suboptimal Drug Concentration"],"prefix":"10.1128","volume":"64","author":[{"given":"Elisabete","family":"Ricardo","sequence":"first","affiliation":[{"name":"Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS \u2013 Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Fr\u00e9deric","family":"Grenouillet","sequence":"additional","affiliation":[{"name":"Medical Biology Department, University Hospital, Besan\u00e7on, France"},{"name":"UMR UBFC-CNRS 6249 ChronoEnvironnement, University of Bourgogne-Franche Comte, Besan\u00e7on, France"}]},{"given":"Isabel M.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Cardiovascular R&amp;D Unit, Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"Raquel M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and iBiMED, University of Aveiro, Aveiro, Portugal"}]},{"given":"Guilluame","family":"Eglin","sequence":"additional","affiliation":[{"name":"Medical Biology Department, University Hospital, Besan\u00e7on, France"}]},{"given":"Nad\u00e8ge","family":"Devillard","sequence":"additional","affiliation":[{"name":"Nephrology Department, University Hospital, Besan\u00e7on, France"}]},{"given":"Ac\u00e1cio Gon\u00e7alves","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS \u2013 Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Burn Unit, Department of Plastic and Reconstructive Surgery, Centro Hospitalar S. Jo\u00e3o, EPE, Porto, Portugal"}]},{"given":"Cid\u00e1lia","family":"Pina-Vaz","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS \u2013 Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir108"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2013.09.004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0865-y"},{"key":"e_1_3_2_5_2","first-page":"764","article-title":"The disposition and metabolism of [14C]fluconazole in humans","volume":"19","author":"Brammer KW","year":"1991","unstructured":"Brammer KW, Coakley AJ, Jezequel SG, Tarbit MH. 1991. The disposition and metabolism of [14C]fluconazole in humans. 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