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We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.<\/jats:p>","DOI":"10.1128\/aac.01668-12","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T06:27:56Z","timestamp":1353997676000},"page":"1053-1056","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["HIV-1 Subtype Is an Independent Predictor of Reverse Transcriptase Mutation K65R in HIV-1 Patients Treated with Combination Antiretroviral Therapy Including Tenofovir"],"prefix":"10.1128","volume":"57","author":[{"given":"K.","family":"Theys","sequence":"first","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, Leuven, Belgium"}]},{"given":"J.","family":"Vercauteren","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, Leuven, Belgium"},{"name":"Faculty of Applied Economics, University of Antwerp, Antwerp, Belgium"}]},{"given":"J.","family":"Snoeck","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, KU Leuven, Leuven, Belgium"},{"name":"Institute of Microbiology, UNIL-CHUV, Lausanne, Switzerland"}]},{"given":"M.","family":"Zazzi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, University of Siena, Siena, Italy"}]},{"given":"R. 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