{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:48:38Z","timestamp":1767962918010,"version":"3.49.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Multidrug-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n            malaria parasites pose a threat to effective drug control, even to artemisinin-based combination therapies (ACTs). Here we used linkage group selection and Solexa whole-genome resequencing to investigate the genetic basis of resistance to component drugs of ACTs. Using the rodent malaria parasite\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. chabaudi<\/jats:named-content>\n            , we analyzed the uncloned progeny of a genetic backcross between the mefloquine-, lumefantrine-, and artemisinin-resistant mutant AS-15MF and a genetically distinct sensitive clone, AJ, following drug treatment. Genomewide scans of selection showed that parasites surviving each drug treatment bore a duplication of a segment of chromosome 12 (translocated to chromosome 04) present in AS-15MF. Whole-genome resequencing identified the size of the duplicated segment and its position on chromosome 4. The duplicated fragment extends for \u223c393 kbp and contains over 100 genes, including\n            <jats:italic>mdr1<\/jats:italic>\n            , encoding the multidrug resistance P-glycoprotein homologue 1. We therefore show that resistance to chemically distinct components of ACTs is mediated by the same genetic mutation, highlighting a possible limitation of these therapies.\n          <\/jats:p>","DOI":"10.1128\/aac.01748-10","type":"journal-article","created":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T09:04:00Z","timestamp":1309251840000},"page":"4858-4865","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Genomewide Scan Reveals Amplification of\n            <i>mdr1<\/i>\n            as a Common Denominator of Resistance to Mefloquine, Lumefantrine, and Artemisinin in Plasmodium chabaudi Malaria Parasites"],"prefix":"10.1128","volume":"55","author":[{"given":"Sofia","family":"Borges","sequence":"first","affiliation":[{"name":"Centro de Mal\u00e1ria e Outras Doen\u00e7as Tropicais\/IHMT\/UEI Malaria, UEI Biologia Molecular, Rua da Junqueira 96, 1349-008 Lisbon, Portugal"}]},{"given":"Pedro","family":"Cravo","sequence":"additional","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Rua 235 s\/n, Setor Universit\u00e1rio, CEP 74605050, Goi\u00e2nia, Brazil"}]},{"given":"Alison","family":"Creasey","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JT, United Kingdom"}]},{"given":"Richard","family":"Fawcett","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JT, United Kingdom"}]},{"given":"Katarzyna","family":"Modrzynska","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JT, United Kingdom"}]},{"given":"Louise","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centro de Mal\u00e1ria e Outras Doen\u00e7as Tropicais\/IHMT\/UEI Malaria, UEI Biologia Molecular, Rua da Junqueira 96, 1349-008 Lisbon, Portugal"}]},{"given":"Axel","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Centro de Mal\u00e1ria e Outras Doen\u00e7as Tropicais\/IHMT\/UEI Malaria, UEI Biologia Molecular, Rua da Junqueira 96, 1349-008 Lisbon, Portugal"}]},{"given":"Paul","family":"Hunt","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JT, United Kingdom"},{"name":"Centre of Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JT, United Kingdom"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","unstructured":"Reference deleted."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1975.11687000"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00947-09"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2006.12.008"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.3.1143"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.2.709-718.2003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2866205"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04748.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.04.008"},{"key":"e_1_3_3_12_2","unstructured":"Reference deleted."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05753.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-499"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(64)90017-7"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-11"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00015-06"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msl185"},{"key":"e_1_3_3_19_2","unstructured":"Reference deleted."},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0805011"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(81)90101-6"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.51.648"},{"key":"e_1_3_3_23_2","unstructured":"Reference deleted."},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00241-08"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.12.2943"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16767-6"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/503423"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/35002615"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.05.005"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/316817a0"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011593"},{"key":"e_1_3_3_32_2","first-page":"8","article-title":"Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia","volume":"12","author":"Rogers W. O.","year":"2009","unstructured":"RogersW. O. . 2009. Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. Malar. J. 12:8\u201310.","journal-title":"Malar. J"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601203"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/261585a0"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1086\/507115"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568011053352587"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1086\/509809"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2006.09.005"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048824"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(93)90252-S"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6071-1"},{"key":"e_1_3_3_42_2","volume-title":"Guidelines for the treatment of malaria","author":"World Health Organization","year":"1996","unstructured":"World Health Organization. 1996. Guidelines for the treatment of malaria. WHO, Geneva, Switzerland."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01748-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01748-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:57:14Z","timestamp":1645480634000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01748-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1128\/AAC.01748-10"],"URL":"https:\/\/doi.org\/10.1128\/aac.01748-10","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"2010-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-06-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}