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This study evaluated the activity of bisnaphthalimidopropyl (BNIP) derivatives against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Trypanosoma brucei<\/jats:named-content>\n            . BNIPDiaminobutane (BNIPDabut), the most active of these compounds, showed\n            <jats:italic>in vitro<\/jats:italic>\n            inhibition in the single-unit nanomolar range, similar to the activity in the reference drug pentamidine, and presented low toxicity and adequate metabolic stability. Additionally, using a murine model of acute infection and live imaging, a significant decrease in parasite load in BNIPDabut-treated mice was observed. However, cure was not achieved. 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