{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:11:04Z","timestamp":1769587864968,"version":"3.49.0"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The purpose of this work was to determine the antimicrobial activity of fluoxetine, alone and combined with fluconazole, against 29<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida<\/jats:named-content>strains isolated from patients with vulvovaginal candidiasis. MIC and minimum lethal concentration values ranged from 9.8 to 625 \u03bcg\/ml for all strains tested. The combination of fluconazole with fluoxetine resulted in synergistic activity against six<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida<\/jats:named-content>strains, with fractional inhibitory index (FIX) values between 0.15 and 0.31. An indifferent effect was found for the remaining strains, with FIX values between 0.63 and 1.<\/jats:p>","DOI":"10.1128\/aac.02623-13","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T03:36:16Z","timestamp":1399347376000},"page":"4224-4226","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Anti-Candida Activity of Fluoxetine Alone and Combined with Fluconazole: a Synergistic Action against Fluconazole-Resistant Strains"],"prefix":"10.1128","volume":"58","author":[{"given":"Ana S.","family":"Oliveira","sequence":"first","affiliation":[{"name":"CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"Carlos A.","family":"Gaspar","sequence":"additional","affiliation":[{"name":"CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal"}]},{"given":"Rita","family":"Palmeira-de-Oliveira","sequence":"additional","affiliation":[{"name":"CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal"},{"name":"Hospital Pharmacy Department, Centro Hospitalar Cova da Beira EPE, Covilh\u00e3, Portugal"}]},{"given":"Jos\u00e9","family":"Martinez-de-Oliveira","sequence":"additional","affiliation":[{"name":"CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal"},{"name":"Child and Women's Health Department, Centro Hospitalar Cova da Beira EPE, Covilh\u00e3, Portugal"}]},{"given":"Ana","family":"Palmeira-de-Oliveira","sequence":"additional","affiliation":[{"name":"CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilh\u00e3, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6176.1450"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000140687.51048.73"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/380637"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3314\/mmj.53.193"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46443-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/138955709789878150"},{"key":"e_1_3_2_8_2","first-page":"57","article-title":"Formula\u00e7\u00f5es com \u00f3leos essenciais: desenvolvimento de um l\u00e1pis medicamentoso de Helichrysum italicum","volume":"1","author":"Palmeira-de-Oliveira R","year":"2011","unstructured":"Palmeira-de-OliveiraRAntunes-ViegasDAmaralMHPalmeira-de-OliveiraASalgueiroLCavaleiroCBreitenfeldLMartinez-de-OliveiraJ. 2011. 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