{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T23:16:26Z","timestamp":1772925386426,"version":"3.50.1"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida albicans<\/jats:named-content>\n            is the most prevalent cause of fungemia worldwide. Its ability to develop resistance in patients receiving azole antifungal therapy is well documented. In a murine model of systemic infection, we show that ibuprofen potentiates fluconazole antifungal activity against a fluconazole-resistant strain, drastically reducing the fungal burden and morbidity. The therapeutic combination of fluconazole with ibuprofen may constitute a new approach for the management of antifungal therapeutics to reverse the resistance conferred by efflux pump overexpression.\n          <\/jats:p>","DOI":"10.1128\/aac.05056-14","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T01:42:34Z","timestamp":1428370954000},"page":"4289-4292","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Ibuprofen Potentiates the\n            <i>In Vivo<\/i>\n            Antifungal Activity of Fluconazole against Candida albicans Murine Infection"],"prefix":"10.1128","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-6615","authenticated-orcid":false,"given":"Sofia","family":"Costa-de-Oliveira","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS\u2014Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Isabel M.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS\u2014Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Ana","family":"Silva-Dias","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS\u2014Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Ana P.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS\u2014Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Ac\u00e1cio G.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS\u2014Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Burn Unit, Department of Plastic and Reconstructive Surgery, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Cid\u00e1lia","family":"Pina-Vaz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS\u2014Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Burn Unit, Department of Plastic and Reconstructive Surgery, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Microbiology, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0448-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.11.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12212"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2008.01.001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1311-1319.2006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1179"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.6.2226-2236.2005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01645-09"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki264"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00504.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl486"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.05.007"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1406(07)70047-5"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00508.x"},{"key":"e_1_3_2_16_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeastsCLSI document M27-A3","author":"CLSI","year":"2008","unstructured":"CLSI. 2008. 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