{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:45:03Z","timestamp":1762004703957},"reference-count":23,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Among the 2,105\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacteriaceae<\/jats:named-content>\n            tested in a survey done in Portugal, 165 were nonsusceptible to carbapenems, from which 35 (26\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella pneumoniae<\/jats:named-content>\n            , 3\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            , 2\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacter aerogenes<\/jats:named-content>\n            , and 3\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacter cloacae<\/jats:named-content>\n            isolates and 1\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella oxytoca<\/jats:named-content>\n            isolate) were confirmed to be carbapenemase producers by the presence of 30\n            <jats:italic>Tn<\/jats:italic>\n            4401d-\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>KPC-3<\/jats:sub>\n            , 4\n            <jats:italic>intI<\/jats:italic>\n            3-\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>GES-5<\/jats:sub>\n            , and one\n            <jats:italic>intI<\/jats:italic>\n            1-\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>VIM-2<\/jats:sub>\n            gene, alone or in combination with other\n            <jats:italic>bla<\/jats:italic>\n            genes. The dissemination of\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>KPC-3<\/jats:sub>\n            gene carried by an IncF plasmid suggests lateral gene transfer as a major mechanism of dissemination.\n          <\/jats:p>","DOI":"10.1128\/aac.05065-14","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T02:56:01Z","timestamp":1426560961000},"page":"3588-3592","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Predominance of KPC-3 in a Survey for Carbapenemase-Producing Enterobacteriaceae in Portugal"],"prefix":"10.1128","volume":"59","author":[{"given":"Vera","family":"Manageiro","sequence":"first","affiliation":[{"name":"National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections (NRL-AMR-HAI), Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"},{"name":"CECA-ICETA, Centro de Estudos de Ci\u00eancia Animal, Universidade do Porto, Porto, Portugal"}]},{"given":"Eug\u00e9nia","family":"Ferreira","sequence":"additional","affiliation":[{"name":"National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections (NRL-AMR-HAI), Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Joana","family":"Almeida","sequence":"additional","affiliation":[{"name":"National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections (NRL-AMR-HAI), Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Stephanie","family":"Barbosa","sequence":"additional","affiliation":[{"name":"National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections (NRL-AMR-HAI), Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Constan\u00e7a","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections (NRL-AMR-HAI), Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"name":"Antibiotic Resistance Surveillance Program in Portugal (ARSIP)","sequence":"additional","affiliation":[]},{"given":"Robert A.","family":"Bonomo","sequence":"additional","affiliation":[{"name":"Research Service, Louis Stokes Cleveland VA Medical Center, Department of Medicine, Pharmacology, Molecular Biology, and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA"}]},{"given":"Manuela","family":"Cani\u00e7a","sequence":"additional","affiliation":[{"name":"National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections (NRL-AMR-HAI), Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.110655"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.02.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"pii=20525","DOI":"10.2807\/1560-7917.ES2013.18.28.20525","article-title":"Carbapenemase-producing Enterobacteriaceae in Europe: a survey among national experts from 39 countries","volume":"18","author":"Glasner C","year":"2013","unstructured":"Glasner C, Albiger B, Buist G, Tambi\u0107 Andrasevi\u0107 A, Canton R, Carmeli Y, Friedrich AW, Giske CG, Glupczynski Y, Gniadkowski M, Livermore DM, Nordmann P, Poirel L, Rossolini GM, Seifert H, Vatopoulos A, Walsh T, Woodford N, Donker T, Monnet DL, Grundmann H, the European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group. 2013. 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