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Both transmission-blocking and blood-schizontocidal activities of the parent drug were conserved only in primacenes bearing a basic aliphatic amine group. Liver stage activity did not require this structural feature, and all metallocenes tested were comparable to or better than primaquine in this regard. Remarkably, the replacement of primaquine's aliphatic chain by hexylferrocene, as in compound 7, led to a \u223c45-fold-higher level activity against liver stage parasitemia than that of primaquine.\n          <\/jats:p>","DOI":"10.1128\/aac.05345-11","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T05:21:18Z","timestamp":1323753678000},"page":"1564-1570","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Novel Potent Metallocenes against Liver Stage Malaria"],"prefix":"10.1128","volume":"56","author":[{"given":"Joana","family":"Matos","sequence":"first","affiliation":[{"name":"CIQUP-Centro de Investiga\u00e7\u00e3o em Qu\u00edmica da Universidade do Porto, Departamento de Qu\u00edmicae Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade do Porto, Porto, Portugal"}]},{"given":"Filipa P.","family":"da Cruz","sequence":"additional","affiliation":[{"name":"Unidade de Mal\u00e1ria, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"\u00c9lia","family":"Cabrita","sequence":"additional","affiliation":[{"name":"Centro de Mal\u00e1ria e Outras Doen\u00e7as Tropicais, IHMT-Universidade Nova de Lisboa, Lisbon, Portugal"}]},{"given":"Jiri","family":"Gut","sequence":"additional","affiliation":[{"name":"Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA"}]},{"given":"F\u00e1tima","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Centro de Mal\u00e1ria e Outras Doen\u00e7as Tropicais, IHMT-Universidade Nova de Lisboa, Lisbon, Portugal"}]},{"given":"Virg\u00edlio E.","family":"do Ros\u00e1rio","sequence":"additional","affiliation":[{"name":"Centro de Mal\u00e1ria e Outras Doen\u00e7as Tropicais, IHMT-Universidade Nova de Lisboa, Lisbon, Portugal"}]},{"given":"Rui","family":"Moreira","sequence":"additional","affiliation":[{"name":"iMed.UL, CECF, Faculdade de Farm\u00e1cia, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Philip J.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA"}]},{"given":"Miguel","family":"Prud\u00eancio","sequence":"additional","affiliation":[{"name":"Unidade de Mal\u00e1ria, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Paula","family":"Gomes","sequence":"additional","affiliation":[{"name":"CIQUP-Centro de Investiga\u00e7\u00e3o em Qu\u00edmica da Universidade do Porto, Departamento de Qu\u00edmicae Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade do Porto, Porto, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1610.100685"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1021\/jm0494624","article-title":"Imidazolidin-4-ones of primaquine as novel transmission-blocking antimalarials","volume":"48","author":"Ara\u00fajo MJ","year":"2005","unstructured":"Ara\u00fajoMJ. 2005. 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