{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T18:13:06Z","timestamp":1778263986861,"version":"3.51.4"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"16","license":[{"start":{"date-parts":[[2011,8,15]],"date-time":"2011-08-15T00:00:00Z","timestamp":1313366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2011,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:named-content content-type=\"genus-species\">Sphingomonadaceae<\/jats:named-content>(<jats:italic>n<\/jats:italic>= 86) were isolated from a drinking water treatment plant (<jats:italic>n<\/jats:italic>= 6), tap water (<jats:italic>n<\/jats:italic>= 55), cup fillers for dental chairs (<jats:italic>n<\/jats:italic>= 21), and a water demineralization filter (<jats:italic>n<\/jats:italic>= 4). The bacterial isolates were identified based on analysis of the 16S rRNA gene sequence, and intraspecies variation was assessed on the basis of<jats:italic>atpD<\/jats:italic>gene sequence analysis. The isolates were identified as members of the genera<jats:named-content content-type=\"genus-species\">Sphingomonas<\/jats:named-content>(<jats:italic>n<\/jats:italic>= 27),<jats:named-content content-type=\"genus-species\">Sphingobium<\/jats:named-content>(<jats:italic>n<\/jats:italic>= 28),<jats:named-content content-type=\"genus-species\">Novosphingobium<\/jats:named-content>(<jats:italic>n<\/jats:italic>= 12),<jats:named-content content-type=\"genus-species\">Sphingopyxis<\/jats:named-content>(<jats:italic>n<\/jats:italic>= 7), and<jats:named-content content-type=\"genus-species\">Blastomonas<\/jats:named-content>(<jats:italic>n<\/jats:italic>= 12). The patterns of susceptibility to five classes of antibiotics were analyzed and compared for the different sites of isolation and taxonomic groups. Colistin resistance was observed to be intrinsic (92%). The highest antibiotic resistance prevalence values were observed in members of the genera<jats:named-content content-type=\"genus-species\">Sphingomonas<\/jats:named-content>and<jats:named-content content-type=\"genus-species\">Sphingobium<\/jats:named-content>and for beta-lactams, ciprofloxacin, and cotrimoxazole. In tap water and in water from dental chairs, antibiotic resistance was more prevalent than in the other samples, mainly due to the predominance of isolates of the genera<jats:named-content content-type=\"genus-species\">Sphingomonas<\/jats:named-content>and<jats:named-content content-type=\"genus-species\">Sphingobium<\/jats:named-content>. These two genera presented distinct patterns of association with antibiotic resistance, suggesting different paths of resistance development. Antibiotic resistance patterns were often related to the species rather than to the site or strain, suggesting the importance of vertical resistance transmission in these bacteria. This is the first study demonstrating that members of the family<jats:named-content content-type=\"genus-species\">Sphingomonadaceae<\/jats:named-content>are potential reservoirs of antibiotic resistance in drinking water.<\/jats:p>","DOI":"10.1128\/aem.00579-11","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T23:16:27Z","timestamp":1309043787000},"page":"5697-5706","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":180,"title":["Diversity and Antibiotic Resistance Patterns of Sphingomonadaceae Isolates from Drinking Water"],"prefix":"10.1128","volume":"77","author":[{"given":"Ivone","family":"Vaz-Moreira","sequence":"first","affiliation":[{"name":"CBQF\/Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, 4200-072 Porto"},{"name":"LEPAE\u2014Departamento de Engenharia Qu\u00edmica, Faculdade de Engenharia, Universidade do Porto, 4200-465 Porto, Portugal"}]},{"given":"Olga C.","family":"Nunes","sequence":"additional","affiliation":[{"name":"LEPAE\u2014Departamento de Engenharia Qu\u00edmica, Faculdade de Engenharia, Universidade do Porto, 4200-465 Porto, Portugal"}]},{"given":"C\u00e9lia M.","family":"Manaia","sequence":"additional","affiliation":[{"name":"CBQF\/Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, 4200-072 Porto"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-30747-8_23"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2008.01711.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.63872-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-010-0449-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jim.2900732"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-005-4048-x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.64915-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2008.01637.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1155157"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.9.5309-5317.2005"},{"key":"e_1_3_2_12_2","volume-title":"Standard methods for the examination of water and wastewater","author":"Eaton A. 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