{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:13:05Z","timestamp":1771945985685,"version":"3.50.1"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"19","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Appl Environ Microbiol"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Anaerobic syntrophic associations of fermentative bacteria and methanogenic archaea operate at the thermodynamic limits of life. The interspecies transfer of electrons from formate or hydrogen as a substrate for the methanogens is key. Contrary requirements of syntrophs and methanogens for growth-sustaining product and substrate concentrations keep the formate and hydrogen concentrations low and within a narrow range. Since formate is a direct substrate for methanogens, a niche for microorganisms that grow by the conversion of formate to hydrogen plus bicarbonate\u2014or vice versa\u2014may seem unlikely. Here we report experimental evidence for growth on formate by syntrophic communities of (i)\n            <jats:italic>Moorella<\/jats:italic>\n            sp. strain AMP in coculture with a thermophilic hydrogen-consuming\n            <jats:italic>Methanothermobacter<\/jats:italic>\n            species and of (ii)\n            <jats:italic>Desulfovibrio<\/jats:italic>\n            sp. strain G11 in coculture with a mesophilic hydrogen consumer,\n            <jats:italic>Methanobrevibacter arboriphilus<\/jats:italic>\n            AZ. In pure culture, neither\n            <jats:italic>Moorella<\/jats:italic>\n            sp. strain AMP, nor\n            <jats:italic>Desulfovibrio<\/jats:italic>\n            sp. strain G11, nor the methanogens grow on formate alone. These results imply the existence of a previously unrecognized microbial niche in anoxic environments.\n          <\/jats:p>","DOI":"10.1128\/aem.01428-08","type":"journal-article","created":{"date-parts":[[2008,8,16]],"date-time":"2008-08-16T00:26:05Z","timestamp":1218846365000},"page":"6126-6131","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":96,"title":["Syntrophic Growth on Formate: a New Microbial Niche in Anoxic Environments"],"prefix":"10.1128","volume":"74","author":[{"given":"Jan","family":"Dolfing","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands"},{"name":"School of Civil Engineering and Geosciences, Newcastle University, Newcastle NE1 7RU, United Kingdom"}]},{"given":"Bo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands"}]},{"given":"Anne M.","family":"Henstra","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands"}]},{"given":"Alfons J. M.","family":"Stams","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands"}]},{"given":"Caroline M.","family":"Plugge","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2001.tb00576.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:BIRY.0000009129.18714.a4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-2920.2003.00419.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.05.028"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.55.7.1735-1741.1989"},{"key":"e_1_3_2_7_2","first-page":"20","volume":"59","year":"1967","unstructured":"Bryant, M. P., E. A. Wolin, M. J. Wolin, and R. 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