{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:09:21Z","timestamp":1776521361634,"version":"3.51.2"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Eukaryot Cell"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Morphogenesis control by chemical signaling molecules is beginning to be highlighted in\n            <jats:italic>Candida<\/jats:italic>\n            biology. The present study focuses on morphogenic compounds produced in situ by\n            <jats:italic>Candida albicans<\/jats:italic>\n            and\n            <jats:italic>Candida dubliniensis<\/jats:italic>\n            during planktonic and biofilm growth that may at least partially substantiate the effect promoted by supernatants in morphogenesis. For both species, planktonic versus biofilm supernatants were analyzed by headspace-solid-phase microextraction and gas chromatography-mass spectrometry. Both planktonic cells and biofilm supernatants of\n            <jats:italic>C. albicans<\/jats:italic>\n            and\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            contained isoamyl alcohol, 2-phenylethanol, 1-dodecanol,\n            <jats:italic>E<\/jats:italic>\n            -nerolidol, and\n            <jats:italic>E<\/jats:italic>\n            ,\n            <jats:italic>E<\/jats:italic>\n            -farnesol. Alcohol secretion profiles were species, culture mode, and growth time specific. The addition of exogenous alcohols to the cultures of both species inhibited the morphological transition from the yeast to the filamentous form by up to 50%. The physiological role of these alcohols was put to evidence by comparing the effects of a 96-h cultured supernatant with synthetic mixtures containing isoamyl alcohol, 2-phenylethanol,\n            <jats:italic>E<\/jats:italic>\n            -nerolidol, and\n            <jats:italic>E<\/jats:italic>\n            ,\n            <jats:italic>E<\/jats:italic>\n            -farnesol at concentrations determined herein. All synthetic mixtures elicited a morphological effect similar to that observed for the corresponding supernatants when used to treat\n            <jats:italic>C. albicans<\/jats:italic>\n            and\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            cultures, except for the effect of the 96-h\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            planktonic supernatant culture on\n            <jats:italic>C. albicans<\/jats:italic>\n            . Overall, these results reveal a group of alcohol extracellular signaling molecules that are biologically active with\n            <jats:italic>C. albicans<\/jats:italic>\n            and\n            <jats:italic>C. dubliniensis<\/jats:italic>\n            morphogenesis.\n          <\/jats:p>","DOI":"10.1128\/ec.00252-07","type":"journal-article","created":{"date-parts":[[2007,11,3]],"date-time":"2007-11-03T00:54:22Z","timestamp":1194051262000},"page":"2429-2436","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":111,"title":["Morphogenesis Control in\n            <i>Candida albicans<\/i>\n            and\n            <i>Candida dubliniensis<\/i>\n            through Signaling Molecules Produced by Planktonic and Biofilm Cells"],"prefix":"10.1128","volume":"6","author":[{"given":"Margarida","family":"Martins","sequence":"first","affiliation":[{"name":"Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Mariana","family":"Henriques","sequence":"additional","affiliation":[{"name":"Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Joana","family":"Azeredo","sequence":"additional","affiliation":[{"name":"Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Si\u0301lvia M.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Departamento de Qui\u0301mica, Universidade de Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Manuel A.","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Departamento de Qui\u0301mica, Universidade de Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Rosa\u0301rio","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00219-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46172-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1411806"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401416101"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2005.11.018"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-142-6-1391"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.43.26871"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211914200"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/322972"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.7.2350-2354.2004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-146-8-1763"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg246"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2006.02044.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04349.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.7.2982-2992.2001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2305-2307.2004"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2006.00121.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.2.902-904.2000"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27739-0"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.163.3863.192"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00634"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.8.4938-4940.2005"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071404698"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400145"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1006\/fstl.2001.0804"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.4.633-638.2005"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.11.5459-5463.2002"},{"key":"e_1_3_2_30_2","first-page":"49","year":"1999","unstructured":"Ritz, K., and J. 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