{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:56:24Z","timestamp":1777679784220,"version":"3.51.4"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Eukaryot Cell"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Trichomonas vaginalis<\/jats:italic>\n                    is one of a few eukaryotes that have been found to encode several homologues of flavodiiron proteins (FDPs). Widespread among anaerobic prokaryotes, these proteins are believed to function as oxygen and\/or nitric oxide reductases to provide protection against oxidative\/nitrosative stresses and host immune responses. One of the\n                    <jats:italic>T. vaginalis<\/jats:italic>\n                    FDP homologues is equipped with a hydrogenosomal targeting sequence and is expressed in the hydrogenosomes, oxygen-sensitive organelles that participate in carbohydrate metabolism and assemble iron-sulfur clusters. The bacterial homologues characterized thus far have been dimers or tetramers; the trichomonad protein is a dimer of identical 45-kDa subunits, each noncovalently binding one flavin mononucleotide. The protein reduces dioxygen to water but is unable to utilize nitric oxide as a substrate, similarly to its closest homologue from another human parasite\n                    <jats:italic>Giardia intestinalis<\/jats:italic>\n                    and related archaebacterial proteins.\n                    <jats:italic>T. vaginalis<\/jats:italic>\n                    FDP is able to accept electrons derived from pyruvate or NADH via ferredoxin and is proposed to play a role in the protection of hydrogenosomes against oxygen.\n                  <\/jats:p>","DOI":"10.1128\/ec.00276-08","type":"journal-article","created":{"date-parts":[[2008,11,14]],"date-time":"2008-11-14T20:55:27Z","timestamp":1226696127000},"page":"47-55","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["Flavodiiron Protein from\n                    <i>Trichomonas vaginalis<\/i>\n                    Hydrogenosomes: the Terminal Oxygen Reductase"],"prefix":"10.1128","volume":"8","author":[{"given":"Tamara","family":"Smutna\u0301","sequence":"first","affiliation":[{"name":"Department of Parasitology, Charles University, Vinic\u030cna\u0301 7, Prague 128 44, Czech Republic"}]},{"given":"Vera L.","family":"Gonc\u0327alves","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qui\u0301mica e Biolo\u0301gica, Universidade Nova de Lisboa, Av. da Repu\u0301blica, EAN, 2780-157 Oeiras, Portugal"}]},{"given":"Li\u0301gia M.","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qui\u0301mica e Biolo\u0301gica, Universidade Nova de Lisboa, Av. da Repu\u0301blica, EAN, 2780-157 Oeiras, Portugal"}]},{"given":"Jan","family":"Tachezy","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Charles University, Vinic\u030cna\u0301 7, Prague 128 44, Czech Republic"}]},{"given":"Miguel","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qui\u0301mica e Biolo\u0301gica, Universidade Nova de Lisboa, Av. da Repu\u0301blica, EAN, 2780-157 Oeiras, Portugal"}]},{"given":"Ivan","family":"Hrdy\u0301","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Charles University, Vinic\u030cna\u0301 7, Prague 128 44, Czech Republic"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-6-27"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00003-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.12.3484"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05719.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132894"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)38131-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02941248"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(85)80026-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1993.tb18162.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1595"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304359200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4716"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705605200"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500349102"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(96)02777-6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02990"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-140-9-2489"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/10.1.21"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/80961"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110471200"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203886200"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.36.22502"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msi245"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.5033-5036.2005"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03149"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01215186"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1995.tb05913.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/7171_2007_110"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)43249-3"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42465-4"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(88)90032-1"},{"key":"e_1_3_2_33_2","first-page":"849","volume":"131","year":"1985","unstructured":"Lloyd, D., and B. Kristensen. 1985. Metronidazole inhibition of hydrogen-production in vivo in drug-sensitive and resistant strains of Trichomonas vaginalis. J. Gen. Microbiol.131:849-853.","journal-title":"J. Gen. Microbiol."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03291"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1990.tb01161.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-139-12-2879"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-05-0434"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.2.300"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2005.04.003"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.8.2745-2751.2006"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2911(04)49002-X"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3413-8"},{"key":"e_1_3_2_44_2","first-page":"126","volume":"182","year":"2004","unstructured":"Seedorf, H., A. Dreisbach, R. Hedderich, S. Shima, and R. K. Thauer. 2004. F420H2 oxidase (FprA) from Methanobrevibacter arboriphilus, a coenzyme F-420-dependent enzyme involved in O2 detoxification. Arch. Microbiol.182:126-137.","journal-title":"Arch. Microbiol."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05706.x"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi027253k"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0477337"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(86)90142-8"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(86)90141-6"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401319101"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(07)37002-X"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506349200"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.14734"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405933200"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2540325.x"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(94)33021-2"}],"container-title":["Eukaryotic Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/EC.00276-08","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/EC.00276-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T09:41:11Z","timestamp":1645609271000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/EC.00276-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1128\/EC.00276-08"],"URL":"https:\/\/doi.org\/10.1128\/ec.00276-08","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1131911.589015","asserted-by":"object"}]},"ISSN":["1535-9778","1535-9786"],"issn-type":[{"value":"1535-9778","type":"print"},{"value":"1535-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]},"assertion":[{"value":"2008-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}