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However, it is not yet clear how this polysaccharide impacts the host immune response and infection-associated pathology. Faster neutrophil recruitment and bacterial clearance were observed in mice challenged intraperitoneally with\n            <jats:named-content content-type=\"genus-species\">S. epidermidis<\/jats:named-content>\n            biofilm cells of the PNAG-producing 9142 strain than in mice similarly challenged with the isogenic PNAG-defective M10 mutant. Moreover, intraperitoneal priming with 9142 cells exacerbated liver inflammatory pathology induced by a subsequent intravenous\n            <jats:named-content content-type=\"genus-species\">S. epidermidis<\/jats:named-content>\n            challenge, compared to priming with M10 cells. The 9142-primed mice had elevated splenic CD4\n            <jats:sup>+<\/jats:sup>\n            T cells producing gamma interferon and interleukin-17A, indicating that PNAG promoted cell-mediated immunity. Curiously, despite having more marked liver tissue pathology, 9142-primed mice also had splenic T regulatory cells with greater suppressive activity than those of their M10-primed counterparts. By showing that PNAG production by\n            <jats:named-content content-type=\"genus-species\">S. epidermidis<\/jats:named-content>\n            biofilm cells exacerbates host inflammatory pathology, these results together suggest that this polysaccharide contributes to the clinical features associated with biofilm-derived infections.\n          <\/jats:p>","DOI":"10.1128\/iai.00290-16","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T03:05:13Z","timestamp":1470107113000},"page":"2933-2943","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Poly-\n            <i>N<\/i>\n            -Acetylglucosamine Production by Staphylococcus epidermidis Cells Increases Their\n            <i>In Vivo<\/i>\n            Proinflammatory Effect"],"prefix":"10.1128","volume":"84","author":[{"given":"Pedro","family":"Ferreirinha","sequence":"first","affiliation":[{"name":"Instituto de 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