{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:44:57Z","timestamp":1771307097561,"version":"3.50.1"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Infect Immun"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Mycobacterium avium<\/jats:italic>\n            is an opportunistic infectious agent in immunocompromised patients, living inside macrophage phagosomes. As for other mycobacterial species, iron availability is a critical factor for\n            <jats:italic>M. avium<\/jats:italic>\n            survival and multiplication. Indeed, an association between host secondary iron overload and increased susceptibility to these mycobacteria is generally acknowledged. However, studies on the impact of primary iron overload on\n            <jats:italic>M. avium<\/jats:italic>\n            infection have not been performed. In this work, we used animal models of primary iron overload that mimic the human disease hereditary hemochromatosis. This pathology is characterized by increased serum transferrin saturation with iron deposition in parenchymal cells, mainly in the liver, and is most often associated with mutations in the gene encoding the molecule HFE. In this paper, we demonstrate that mice of two genetically determined primary iron overload phenotypes, Hfe\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            and \u03b22m\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            , show an increased susceptibility to experimental infection with\n            <jats:italic>M. avium<\/jats:italic>\n            and that during infection these animals accumulate iron inside granuloma macrophages. \u03b22m\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice were found to be more susceptible than Hfe\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice, but depleting Hfe\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice of CD8\n            <jats:sup>+<\/jats:sup>\n            cells had no effect on resistance to infection. Overall, our results suggest that serum iron, rather than total liver iron, levels have a considerable impact on susceptibility to\n            <jats:italic>M. avium<\/jats:italic>\n            infection.\n          <\/jats:p>","DOI":"10.1128\/iai.00612-08","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T00:43:42Z","timestamp":1218501822000},"page":"4713-4719","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Increased Susceptibility to\n            <i>Mycobacterium avium<\/i>\n            in Hemochromatosis Protein HFE-Deficient Mice"],"prefix":"10.1128","volume":"76","author":[{"given":"Sandra","family":"Gomes-Pereira","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology and Immunology of Infection"},{"name":"Escola Superior de Tecnologia da Sau\u0301de do Porto, Instituto Polite\u0301cnico do Porto, Porto, Portugal"}]},{"given":"Pedro Nuno","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Iron Genes and the Immune System, IBMC\u2014Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal"},{"name":"ICBAS\u2014Instituto de Cie\u0302ncias Biome\u0301dicas de Abel Salazar, Universidade do Porto, Porto, Portugal"}]},{"given":"Rui","family":"Appelberg","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Immunology of Infection"},{"name":"ICBAS\u2014Instituto de Cie\u0302ncias Biome\u0301dicas de Abel Salazar, Universidade do Porto, Porto, Portugal"}]},{"given":"Maria Salome\u0301","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Immunology of Infection"},{"name":"ICBAS\u2014Instituto de Cie\u0302ncias Biome\u0301dicas de Abel Salazar, Universidade do Porto, Porto, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.9.3962-3971.1994"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13312"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.6.3108-3111.1999"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/518040"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.7.2546"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(94)90094-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.22.14025"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.24.12013"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/323203"},{"key":"e_1_3_2_11_2","first-page":"183","volume":"306","year":"2006","unstructured":"Ganz, T. 2006. 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