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Understanding how bacterial CF pathogens thrive in this environment might help the development of new therapeutic interventions to prevent chronic respiratory infections. Here, we show that the OmpR response regulator of one of the species found in CF respiratory infections,\n            <jats:named-content content-type=\"genus-species\">Burkholderia multivorans<\/jats:named-content>\n            , is involved in the emergence of nonmucoid colony variants and is important for osmoadaptation by regulating several cell envelope components. Specifically, genetic, phenotypic, genomic, and transcriptomic approaches uncover OmpR as a regulator of cell wall remodeling under stress conditions, with implications in several phenotypes such as exopolysaccharide production, motility, antibiotic resistance, adhesion, and virulence.\n          <\/jats:p>","DOI":"10.1128\/jb.00216-18","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T10:18:13Z","timestamp":1529403493000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["The OmpR Regulator of Burkholderia multivorans Controls Mucoid-to-Nonmucoid Transition and Other Cell Envelope Properties Associated with Persistence in the Cystic Fibrosis Lung"],"prefix":"10.1128","volume":"200","author":[{"given":"In\u00eas N.","family":"Silva","sequence":"first","affiliation":[{"name":"IBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Filipa D.","family":"Pessoa","sequence":"additional","affiliation":[{"name":"IBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Marcelo J.","family":"Ramires","sequence":"additional","affiliation":[{"name":"IBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"M\u00e1rio R.","family":"Santos","sequence":"additional","affiliation":[{"name":"IBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"J\u00f6rg D.","family":"Becker","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7726-0765","authenticated-orcid":false,"given":"Vaughn S.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, Center for Evolutionary Biology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-4245","authenticated-orcid":false,"given":"Leonilde M.","family":"Moreira","sequence":"additional","affiliation":[{"name":"IBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisbon, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2011.00016"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3059"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01828-09"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.10.118"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00694-15"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180362"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510692200"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/423141"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00998.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.7.3052-3058.2004"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01450-06"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.4.1651-1655.2000"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2008\/019216-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02273-07"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201002-0203OC"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082522"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00874-07"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00029-16"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.213363.116"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01531-14"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(97)00170-6"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00222-13"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.61"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00018"},{"key":"e_1_3_3_26_2","first-page":"412","article-title":"Regulation of Vi capsular polysaccharide synthesis in Salmonella enterica serotype Typhi","volume":"2","author":"Santander J","year":"2008","unstructured":"Santander J, Roland KL, Curtiss R 3rd. 2008. 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