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The transcriptional regulator CsgD is the major target for these regulatory pathways. In this study, we show that two lytic transglycosylases of family I, MltE and MltC, in combination increase CsgD expression and rdar morphotype. MltE and MltC, which share a highly similar transglycosylase SLT domain, work redundantly to regulate CsgD at the transcriptional and posttranscriptional levels. The effect of MltE and MltC on CsgD levels was independent of the known regulatory pathways that sense cell envelope stress. These findings reveal, for the first time, a specific function of lytic transglycosylases in\n            <jats:italic>S<\/jats:italic>\n            . Typhimurium and suggest the existence of a new signaling pathway that links cell wall turnover to biofilm formation.\n          <\/jats:p>","DOI":"10.1128\/jb.00425-11","type":"journal-article","created":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T03:29:09Z","timestamp":1317439749000},"page":"6443-6451","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":41,"title":["Regulation of Biofilm Components in Salmonella enterica Serovar Typhimurium by Lytic Transglycosylases Involved in Cell Wall Turnover"],"prefix":"10.1128","volume":"193","author":[{"given":"Claudia","family":"Monteiro","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden"}]},{"given":"Xin","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 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