{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:18:43Z","timestamp":1761110323701},"reference-count":67,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Luso-American Foundation for Development (FLAD), Portugal\u2013Luso-American Collaborative Response Award on HIV\/AIDS"},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, Portugal","award":["PTDC\/BIM-MEC\/6631\/2014"],"award-info":[{"award-number":["PTDC\/BIM-MEC\/6631\/2014"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            HIV plasma viral load is an established marker of disease progression and of response to antiretroviral therapy, but currently there is no commercial assay validated for the quantification of viral load in HIV-2-infected individuals. We sought to make the first clinical evaluation of Cavidi ExaVir Load (version 3) in HIV-2-infected patients. Samples were collected from a total of 102 individuals living in Cape Verde, and the HIV-2 viral load was quantified by both ExaVir Load and a reference in-house real-time quantitative PCR (qPCR) used in Portugal in 91 samples. The associations between viral load and clinical prognostic variables (CD4\n            <jats:sup>+<\/jats:sup>\n            T cell counts and antiretroviral therapy status) were similar for measurements obtained using ExaVir Load and qPCR. There was no difference between the two methods in the capacity to discriminate between nonquantifiable and quantifiable HIV-2 in the plasma. In samples with an HIV-2 viral load quantifiable by both methods (\n            <jats:italic>n<\/jats:italic>\n            = 27), the measurements were highly correlated (Pearson\n            <jats:italic>r<\/jats:italic>\n            = 0.908), but the ExaVir Load values were systematically higher relative to those determined by qPCR (median difference, 0.942 log\n            <jats:sub>10<\/jats:sub>\n            copies\/ml). A regression model was derived that enables the conversion of ExaVir Load results to those that would have been obtained by the reference qPCR. In conclusion, ExaVir Load version 3 is a reliable commercial assay to measure viral load in HIV-2-infected patients and therefore a valuable alternative to the in-house assays in current use.\n          <\/jats:p>","DOI":"10.1128\/jcm.00235-17","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T00:40:32Z","timestamp":1495068032000},"page":"2367-2379","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of the Cavidi ExaVir Load Assay for Monitoring Plasma Viral Load in HIV-2-Infected Patients"],"prefix":"10.1128","volume":"55","author":[{"given":"Pedro","family":"Borrego","sequence":"first","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Centro de Administra\u00e7\u00e3o e Pol\u00edticas P\u00fablicas, Instituto Superior de Ci\u00eancias Sociais e Pol\u00edticas, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Superior de Ci\u00eancias da Sa\u00fade Egas Moniz, Monte de Caparica, Portugal"}]},{"given":"Maria F\u00e1tima","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, LMCBM, SPC, Centro Hospitalar Lisboa Ocidental\u2014HEM, Lisbon, Portugal"}]},{"given":"Perp\u00e9tua","family":"Gomes","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Superior de Ci\u00eancias da Sa\u00fade Egas Moniz, Monte de Caparica, Portugal"},{"name":"Laborat\u00f3rio de Biologia Molecular, LMCBM, SPC, Centro Hospitalar Lisboa Ocidental\u2014HEM, Lisbon, Portugal"}]},{"given":"Lav\u00ednia","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"In\u00eas","family":"Moranguinho","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"In\u00eas Brito","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Superior de Ci\u00eancias da Sa\u00fade Egas Moniz, Monte de Caparica, Portugal"}]},{"given":"Isabel","family":"Barahona","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Superior de Ci\u00eancias da Sa\u00fade Egas Moniz, Monte de Caparica, Portugal"}]},{"given":"Jos\u00e9","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio ELISA, Hospital Agostinho Neto, Praia, Cabo Verde"}]},{"given":"Claudino","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio ELISA, Hospital Agostinho Neto, Praia, Cabo Verde"}]},{"given":"Maria Cesarina","family":"Cruz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de An\u00e1lises Cl\u00ednicas, Delegacia de Sa\u00fade, S. 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