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We have characterized the serotype 19A isolates (<jats:italic>n<\/jats:italic>= 288) found among pneumococci responsible for infections (<jats:italic>n<\/jats:italic>= 1,925) and pneumococci recovered from asymptomatic carriers (<jats:italic>n<\/jats:italic>= 1,973) in Portugal between 2001 and 2006. We show that despite the existence of serotype 19A clones that have a greater potential to cause invasive disease or an enhanced colonization capacity, the lineage that is increasing as a cause of infection in Portugal is a multiresistant clone that is competent at both. The expanding Denmark<jats:sup>14<\/jats:sup>-230 clone found in Portugal is disseminated in other Mediterranean countries, where it is also increasingly responsible for invasive infections in both children and adults. The lineages driving the rise of serotype 19A infections in Asia and the United States (sequence type 320 [ST320] and ST199) are either absent or account for only a small proportion of isolates in Portugal. These data highlight the importance of locally circulating clones with the ability to compete in the nasopharyngeal niche in the emergence of the serotype 19A lineages which are an increasing cause of infection in various geographic regions.<\/jats:p>","DOI":"10.1128\/jcm.00665-09","type":"journal-article","created":{"date-parts":[[2009,10,29]],"date-time":"2009-10-29T01:24:16Z","timestamp":1256779456000},"page":"101-108","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Denmark<sup>14<\/sup>-230 Clone as an Increasing Cause of Pneumococcal Infection in Portugal within a Background of Diverse Serotype 19A Lineages"],"prefix":"10.1128","volume":"48","author":[{"given":"Sandra I.","family":"Aguiar","sequence":"first","affiliation":[{"name":"Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Francisco R.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Centro de Qui\u0301mica e Bioqui\u0301mica, Departamento de Qui\u0301mica e Bioqui\u0301mica, Faculdade de Cie\u0302ncias da Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"So\u0301nia","family":"Nunes","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qui\u0301mica e Biolo\u0301gica, Universidade Nova de Lisboa, Oeiras, Portugal"}]},{"given":"Isa","family":"Serrano","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Jose\u0301","family":"Melo-Cristino","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Raquel","family":"Sa\u0301-Lea\u0303o","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qui\u0301mica e Biolo\u0301gica, Universidade Nova de Lisboa, Oeiras, Portugal"},{"name":"Centro de Matema\u0301tica e Aplicac\u0327o\u0303es Fundamentais, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Ma\u0301rio","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Hermi\u0301nia","family":"de Lencastre","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qui\u0301mica e Biolo\u0301gica, Universidade Nova de Lisboa, Oeiras, Portugal"},{"name":"Laboratory of Microbiology, The Rockefeller University, New York, New York"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Agresti A. 1990. 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