{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:46:14Z","timestamp":1777430774672,"version":"3.51.4"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Candida rugosa<\/jats:italic>\n            is a fungus that appears to be emerging as a cause of infection in some geographic regions. We utilized the extensive database of the ARTEMIS DISK Antifungal Surveillance Program to describe the geographic and temporal trends in the isolation of\n            <jats:italic>C. rugosa<\/jats:italic>\n            from clinical specimens and the in vitro susceptibilities of 452 isolates to fluconazole and voriconazole.\n            <jats:italic>C. rugosa<\/jats:italic>\n            accounted for 0.4% of 134,715 isolates of\n            <jats:italic>Candida<\/jats:italic>\n            , and the frequency of isolation increased from 0.03% to 0.4% over the 6.5-year study period (1997 to 2003).\n            <jats:italic>C. rugosa<\/jats:italic>\n            was most common in the Latin American region (2.7% versus 0.1 to 0.4%). Decreased susceptibility to fluconazole (40.5% susceptible) was observed in all geographic regions; however, isolates from Europe and North America were much more susceptible (97 to 100%) to voriconazole than those from other geographic regions (55.8 to 58.8%).\n            <jats:italic>C. rugosa<\/jats:italic>\n            was most often isolated from blood and urine in patients hospitalized at the Medical and Surgical inpatient services. Notably, bloodstream isolates were the least susceptible to both fluconazole and voriconazole.\n            <jats:italic>C. rugosa<\/jats:italic>\n            should be considered, along with the established pathogens\n            <jats:italic>Candida krusei<\/jats:italic>\n            and\n            <jats:italic>Candida glabrata<\/jats:italic>\n            , as a species of\n            <jats:italic>Candida<\/jats:italic>\n            with reduced susceptibility to the azole antifungal agents.\n          <\/jats:p>","DOI":"10.1128\/jcm.00863-06","type":"journal-article","created":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T17:59:53Z","timestamp":1159984793000},"page":"3578-3582","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":83,"title":["<i>Candida rugosa<\/i>\n            , an Emerging Fungal Pathogen with Resistance to Azoles: Geographic and Temporal Trends from the ARTEMIS DISK Antifungal Surveillance Program"],"prefix":"10.1128","volume":"44","author":[{"given":"M. A.","family":"Pfaller","sequence":"first","affiliation":[{"name":"University of Iowa College of Medicine, Iowa City, Iowa"}]},{"given":"D. J.","family":"Diekema","sequence":"additional","affiliation":[{"name":"University of Iowa College of Medicine, Iowa City, Iowa"}]},{"given":"A. L.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina, Sao Paulo, Brazil"}]},{"given":"C.","family":"Kibbler","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom"}]},{"given":"K. P.","family":"Ng","sequence":"additional","affiliation":[{"name":"University Malaya, Kuala Lumpur, Malaysia"}]},{"given":"D. L.","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Giles Scientific, Inc., Santa Barbara, California"}]},{"given":"V. A.","family":"Newell","sequence":"additional","affiliation":[{"name":"Giles Scientific, Inc., Santa Barbara, California"}]},{"name":"the Global Antifungal Surveillance Group","sequence":"additional","affiliation":[]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(99)00042-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(03)00079-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.1.77"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.12.5623-5632.2003"},{"key":"e_1_3_2_6_2","unstructured":"National Committee for Clinical Laboratory Standards. 2004. Method for antifungal disk diffusion susceptibility testing of yeasts: approved guidance M44-A. 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