{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:10:43Z","timestamp":1771636243203,"version":"3.50.1"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Although a rare cause of invasive candidiasis,\n            <jats:italic>Candida guilliermondii<\/jats:italic>\n            has been reported to exhibit decreased susceptibility to antifungal agents. Aside from case reports and small surveys, there is little information regarding the epidemiology and antifungal susceptibility profile of\n            <jats:italic>C. guilliermondii<\/jats:italic>\n            . We report geographic and temporal trends in the isolation and antifungal susceptibilities of 1,029\n            <jats:italic>C. guilliermondii<\/jats:italic>\n            clinical isolates collected from 127 medical centers as part of the ARTEMIS DISK Antifungal Surveillance Program. In addition, we report the in vitro susceptibility of 132 bloodstream isolates of\n            <jats:italic>C. guilliermondii<\/jats:italic>\n            to caspofungin.\n            <jats:italic>C. guilliermondii<\/jats:italic>\n            represented 1.4% of the 75,761 isolates collected from 2001 to 2003 and was most common among isolates from Latin America (3.7% versus 0.6 to 1.1%). Decreased susceptibility to fluconazole was noted (75% susceptible; range, 68 to 77% across regions), and voriconazole was more active in vitro against\n            <jats:italic>C. guilliermondii<\/jats:italic>\n            than fluconazole (91% susceptible; range, 88 to 93% across regions). Fluconazole was least active against isolates from dermatology (58%) and surgical (69%) services and against isolates associated with skin and soft tissue infection (68%, compared to 85% susceptible for bloodstream isolates). There was no evidence of increasing azole resistance over time among\n            <jats:italic>C. guilliermondii<\/jats:italic>\n            isolates tested from 2001 to 2003. Of 132 bloodstream isolates of\n            <jats:italic>C. guilliermondii<\/jats:italic>\n            tested against caspofungin, most were inhibited by \u22642 \u03bcg\/ml (96%; MIC\n            <jats:sub>50<\/jats:sub>\n            \/MIC\n            <jats:sub>90<\/jats:sub>\n            , 0.5\/1.0 \u03bcg\/ml).\n            <jats:italic>C. guilliermondii<\/jats:italic>\n            , a species that exhibits reduced susceptibility to fluconazole, is the sixth most frequently isolated\n            <jats:italic>Candida<\/jats:italic>\n            species from this large survey and may be an emerging pathogen in Latin America.\n          <\/jats:p>","DOI":"10.1128\/jcm.00865-06","type":"journal-article","created":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T17:59:53Z","timestamp":1159984793000},"page":"3551-3556","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":160,"title":["<i>Candida guilliermondii<\/i>\n            , an Opportunistic Fungal Pathogen with Decreased Susceptibility to Fluconazole: Geographic and Temporal Trends from the ARTEMIS DISK Antifungal Surveillance Program"],"prefix":"10.1128","volume":"44","author":[{"given":"M. A.","family":"Pfaller","sequence":"first","affiliation":[{"name":"University of Iowa College of Medicine, Iowa City, Iowa"}]},{"given":"D. J.","family":"Diekema","sequence":"additional","affiliation":[{"name":"University of Iowa College of Medicine, Iowa City, Iowa"}]},{"given":"M.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Hospital Militar Central, Bogota\u0301, Columbia"}]},{"given":"C.","family":"Kibbler","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, United Kingdom"}]},{"given":"P.","family":"Erzsebet","sequence":"additional","affiliation":[{"name":"ANTSZ BAZ Megyei Intezete, Miscolc, Hungary"}]},{"given":"S.-C.","family":"Chang","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital, Taipei, Taiwan"}]},{"given":"D. L.","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Giles Scientific, Inc., Santa Barbara, California"}]},{"given":"V. A.","family":"Newell","sequence":"additional","affiliation":[{"name":"Giles Scientific, Inc., Santa Barbara, California"}]},{"name":"the Global Antifungal Surveillance Group","sequence":"additional","affiliation":[]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf060"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-1-67"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107754"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00356-06"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.12.5623-5632.2003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-1013-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021585"},{"key":"e_1_3_2_9_2","unstructured":"National Committee for Clinical Laboratory Standards. 2002. 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