{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:42:08Z","timestamp":1762004528845},"reference-count":22,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In the absence of clinical breakpoints (CBP), epidemiological cutoff values (ECVs) are useful to separate wild-type (WT) isolates (without mechanisms of resistance) from non-WT isolates (those that can harbor some resistance mechanisms), which is the goal of susceptibility tests. Sensititre YeastOne (SYO) is a widely used method to determine susceptibility of\n            <jats:named-content content-type=\"genus-species\">Candida<\/jats:named-content>\n            spp. to antifungal agents. The CLSI CBP have been established, but not for the SYO method. The ECVs for four azoles, obtained using MIC distributions determined by the SYO method, were calculated via five methods (three statistical methods and based on the MIC\n            <jats:sub>50<\/jats:sub>\n            and modal MIC). Respectively, the median ECVs (in mg\/liter) of the five methods for fluconazole, itraconazole, posaconazole, and voriconazole (in parentheses: the percentage of isolates inhibited by MICs equal to or less than the ECVs; the number of isolates tested) were as follows: 2 (94.4%; 944), 0.5 (96.7%; 942), 0.25 (97.6%; 673), and 0.06 (96.7%; 849) for\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            ; 4 (86.1%; 642), 0.5 (99.4%; 642), 0.12 (93.9%; 392), and 0.06 (86.9%; 559) for\n            <jats:named-content content-type=\"genus-species\">C. parapsilosis<\/jats:named-content>\n            ; 8 (94.9%; 175), 1 (93.7%; 175), 2 (93.6%; 125), and 0.25 (90.4%; 167) for\n            <jats:named-content content-type=\"genus-species\">C. tropicalis<\/jats:named-content>\n            ; 128 (98.6%; 212), 4 (95.8%; 212), 4 (96.0%; 173), and 2 (98.5; 205) for\n            <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n            ; 256 (100%; 53), 1 (98.1%; 53), 1 (100%; 33), and 1 (97.9%; 48) for\n            <jats:named-content content-type=\"genus-species\">C. krusei<\/jats:named-content>\n            ; 4 (89.2%; 93), 0.5 (100%; 93), 0.25 (100%; 33), and 0.06 (87.7%; 73) for\n            <jats:named-content content-type=\"genus-species\">C. orthopsilosis<\/jats:named-content>\n            . All methods included \u226594% of isolates and yielded similar ECVs (within 1 dilution). These ECVs would be suitable for monitoring emergence of isolates with reduced susceptibility by using the SYO method.\n          <\/jats:p>","DOI":"10.1128\/jcm.01230-13","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T03:53:26Z","timestamp":1371095606000},"page":"2691-2695","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Epidemiological Cutoff Values for Fluconazole, Itraconazole, Posaconazole, and Voriconazole for Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method"],"prefix":"10.1128","volume":"51","author":[{"given":"Emilia","family":"Cant\u00f3n","sequence":"first","affiliation":[{"name":"Unidad de Microbiolog\u00eda Experimental, Centro de Investigaci\u00f3n, Hospital La Fe, Valencia, Spain"}]},{"given":"Javier","family":"Pem\u00e1n","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital La Fe, Valencia, Spain"}]},{"given":"Carmen","family":"I\u00f1iguez","sequence":"additional","affiliation":[{"name":"\u00c1rea de Ambiente y Salud, Centro Investigaci\u00f3n Salud P\u00fablica, Valencia, Spain"},{"name":"Universidad de Valencia, Valencia, Spain"}]},{"given":"David","family":"Herv\u00e1s","sequence":"additional","affiliation":[{"name":"Unidad Bioestadistica, Valencia, Spain"}]},{"given":"Jose L.","family":"Lopez-Hontangas","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital La Fe, Valencia, Spain"}]},{"given":"Cidalia","family":"Pina-Vaz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Cardiovascular Research and Development Unit, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Department of Microbiology, Hospital S. Jo\u00e3o, Porto, Portugal"}]},{"given":"Juan J.","family":"Camarena","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Peset, Valencia, Spain"}]},{"given":"Isolina","family":"Campos-Herrero","sequence":"additional","affiliation":[{"name":"Hospital de Gran Canaria Dr. Negr\u00edn, Las Palmas de Gran Canaria, Las Palmas, Spain"}]},{"given":"Inmaculada","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario, Salamanca, Spain"}]},{"given":"Ana M.","family":"Garc\u00eda-Tapia","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta del Mar, C\u00e1diz, Spain"}]},{"given":"Remedios","family":"Guna","sequence":"additional","affiliation":[{"name":"Hospital General, Valencia, Spain"}]},{"given":"Paloma","family":"Merino","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos, Madrid, Spain"}]},{"given":"Luisa","family":"P\u00e9rez del Molino","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario, Santiago de Compostela, Spain"}]},{"given":"Carmen","family":"Rubio","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Lozano Blesa, Zaragoza, Spain"}]},{"given":"Anabel","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Macarena, Seville, Spain"}]},{"name":"FUNGEMYCA Study Group","sequence":"additional","affiliation":[]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780701218689"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/513640"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01256-09"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00156-08"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01730-12"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01101-10"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01377.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/596757"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00466-11"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00504.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01127-10"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00686-11"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg312"},{"key":"e_1_3_2_15_2","unstructured":"R Core Team. 2012. R: a language and environment for statistical computing. R Foundation for Statistical Computing Vienna Austria. http:\/\/www.R-project.org\/."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks019"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01840-06"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000048583"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.2.718-721.2004"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02161-10"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00248-12"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.09.002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05047-11"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01230-13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.01230-13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:46:20Z","timestamp":1646480780000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.01230-13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1128\/JCM.01230-13"],"URL":"https:\/\/doi.org\/10.1128\/jcm.01230-13","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"type":"print","value":"0095-1137"},{"type":"electronic","value":"1098-660X"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"2013-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}