{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:29:30Z","timestamp":1771540170625,"version":"3.50.1"},"reference-count":56,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            VRE isolates from pigs (\n            <jats:italic>n<\/jats:italic>\n            = 29) and healthy persons (\n            <jats:italic>n<\/jats:italic>\n            = 12) recovered during wide surveillance studies performed in Portugal, Denmark, Spain, Switzerland, and the United States (1995 to 2008) were compared with outbreak\/prevalent VRE clinical strains (\n            <jats:italic>n<\/jats:italic>\n            = 190; 23 countries; 1986 to 2009). Thirty clonally related\n            <jats:named-content content-type=\"genus-species\">Enterococcus faecium<\/jats:named-content>\n            clonal complex 5 (CC5) isolates (17 sequence type 6 [ST6], 6 ST5, 5 ST185, 1 ST147, and 1 ST493) were obtained from feces of swine and healthy humans. This collection included isolates widespread among pigs of European Union (EU) countries since the mid-1990s. Each ST comprised isolates showing similar pulsed-field gel electrophoresis (PFGE) patterns (\u22646 bands difference; &gt;82% similarity). Some CC5 PFGE subtype strains from swine were indistinguishable from hospital vancomycin-resistant enterococci (VRE) causing infections. A truncated variant of Tn\n            <jats:italic>1546<\/jats:italic>\n            (encoding resistance to vancomycin) and\n            <jats:italic>tcrB<\/jats:italic>\n            (coding for resistance to copper) were consistently located on 150- to 190-kb plasmids (rep\n            <jats:sub>pLG1<\/jats:sub>\n            ).\n            <jats:named-content content-type=\"genus-species\">E. faecium<\/jats:named-content>\n            CC17 (ST132) isolates from pig manure and two clinical samples showed identical PFGE profiles and contained a 60-kb mosaic plasmid (rep\n            <jats:sub>Inc18<\/jats:sub>\n            plus rep\n            <jats:sub>pRUM<\/jats:sub>\n            ) carrying diverse Tn\n            <jats:italic>1546<\/jats:italic>\n            -IS\n            <jats:italic>1216<\/jats:italic>\n            variants. The only\n            <jats:named-content content-type=\"genus-species\">Enterococcus faecalis<\/jats:named-content>\n            isolate obtained from pigs (CC2-ST6) corresponded to a multidrug-resistant clone widely disseminated in hospitals in Italy, Portugal, and Spain, and both animal and human isolates harbored an indistinguishable 100-kb mosaic plasmid (rep\n            <jats:sub>pRE25<\/jats:sub>\n            plus rep\n            <jats:sub>pCF10<\/jats:sub>\n            ) containing the whole Tn\n            <jats:italic>1546<\/jats:italic>\n            backbone. The results indicate a current intra- and international spread of\n            <jats:named-content content-type=\"genus-species\">E. faecium<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">E. faecalis<\/jats:named-content>\n            clones and their plasmids among swine and humans.\n          <\/jats:p>","DOI":"10.1128\/jcm.01750-10","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T03:21:49Z","timestamp":1294888909000},"page":"925-931","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":124,"title":["Human and Swine Hosts Share Vancomycin-Resistant Enterococcus faecium CC17 and CC5 and Enterococcus faecalis CC2 Clonal Clusters Harboring Tn\n            <i>1546<\/i>\n            on Indistinguishable Plasmids"],"prefix":"10.1128","volume":"49","author":[{"given":"Ana R.","family":"Freitas","sequence":"first","affiliation":[{"name":"REQUIMTE, Laborat\u00f3rio de Microbiologia, Faculdade de Farm\u00e1cia, Universidade do Porto, Porto, Portugal"},{"name":"Servicio de Microbiolog\u00eda, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), Madrid, Spain"}]},{"given":"Teresa M.","family":"Coque","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), Madrid, Spain"},{"name":"Unidad de Resistencia a Antibi\u00f3ticos y Virulencia Bacteriana (RYC-CSIC), Madrid, Spain"},{"name":"Ciber en Epidemiolog\u00eda y Salud P\u00fablica (CIBER-ESP), Madrid, Spain"}]},{"given":"Carla","family":"Novais","sequence":"additional","affiliation":[{"name":"REQUIMTE, Laborat\u00f3rio de Microbiologia, Faculdade de Farm\u00e1cia, Universidade do Porto, Porto, Portugal"},{"name":"CEBIMED, Faculdade Ci\u00eancias da Sa\u00fade, Universidade Fernando Pessoa, Porto, Portugal"}]},{"given":"Anette M.","family":"Hammerum","sequence":"additional","affiliation":[{"name":"Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark"}]},{"given":"Camilla H.","family":"Lester","sequence":"additional","affiliation":[{"name":"Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark"}]},{"given":"Marcus J.","family":"Zervos","sequence":"additional","affiliation":[{"name":"Henry Ford Health System, Detroit, Michigan"},{"name":"Wayne State University School of Medicine, Detroit, Michigan"}]},{"given":"Susan","family":"Donabedian","sequence":"additional","affiliation":[{"name":"Henry Ford Health System, Detroit, Michigan"}]},{"given":"Lars B.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Division of Microbiology and Risk Assessment, National Food Institute, Danish Technical University, Copenhagen V, Denmark"}]},{"given":"Maria Victoria","family":"Francia","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Marqu\u00e9s de Valdecilla e Instituto de Formaci\u00f3n e Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IFIMAV), Santander, Spain"}]},{"given":"Fernando","family":"Baquero","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), Madrid, Spain"},{"name":"Unidad de Resistencia a Antibi\u00f3ticos y Virulencia Bacteriana (RYC-CSIC), Madrid, Spain"},{"name":"Ciber en Epidemiolog\u00eda y Salud P\u00fablica (CIBER-ESP), Madrid, Spain"}]},{"given":"Lu\u00edsa","family":"Peixe","sequence":"additional","affiliation":[{"name":"REQUIMTE, Laborat\u00f3rio de Microbiologia, Faculdade de Farm\u00e1cia, Universidade do Porto, Porto, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn271"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00242-09"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/34.4.507"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02239-06"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.11.4193-4195.2001"},{"key":"e_1_3_3_7_2","unstructured":"Clinical Laboratory Standards Institute. 2010. 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