{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:03:47Z","timestamp":1778029427164,"version":"3.51.4"},"reference-count":61,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Candida krusei<\/jats:italic>\n            is well known as a fungal pathogen for patients with hematologic malignancies and for transplant recipients. Using the ARTEMIS Antifungal Surveillance Program database, we describe geographic and temporal trends in the isolation of\n            <jats:italic>C. krusei<\/jats:italic>\n            from clinical specimens and the in vitro susceptibilities of 3,448 isolates to voriconazole as determined by CLSI (formerly NCCLS) disk diffusion testing. In addition, we report the in vitro susceptibilities of bloodstream infection isolates of\n            <jats:italic>C. krusei<\/jats:italic>\n            to amphotericin B (304 isolates), flucytosine (254 isolates), anidulafungin (121 isolates), caspofungin (300 isolates), and micafungin (102 isolates) as determined by CLSI broth microdilution methods. Geographic differences in isolation were apparent; the highest frequency of isolation was seen for the Czech Republic (7.6%) and the lowest for Indonesia, South Korea, and Thailand (0 to 0.3%). Overall, 83% of isolates were susceptible to voriconazole, ranging from 74.8% in Latin America to 92.3% in North America.\n            <jats:italic>C. krusei<\/jats:italic>\n            was most commonly isolated from hematology-oncology services, where only 76.7% of isolates were susceptible to voriconazole. There was no evidence of increasing resistance of\n            <jats:italic>C. krusei<\/jats:italic>\n            to voriconazole from 2001 to 2005. Decreased susceptibilities to amphotericin B (MIC at which 90% of isolates were inhibited [MIC\n            <jats:sub>90<\/jats:sub>\n            ], 4 \u03bcg\/ml) and flucytosine (MIC\n            <jats:sub>90<\/jats:sub>\n            , 16 \u03bcg\/ml) were noted, whereas 100% of isolates were inhibited by \u22642 \u03bcg\/ml of anidulafungin (MIC\n            <jats:sub>90<\/jats:sub>\n            , 0.06 \u03bcg\/ml), micafungin (MIC\n            <jats:sub>90<\/jats:sub>\n            , 0.12 \u03bcg\/ml) or caspofungin (MIC\n            <jats:sub>90<\/jats:sub>\n            , 0.25 \u03bcg\/ml).\n            <jats:italic>C. krusei<\/jats:italic>\n            is an uncommon but multidrug-resistant fungal pathogen. Among the systemically active antifungal agents, the echinocandins appear to be the most active against this important pathogen.\n          <\/jats:p>","DOI":"10.1128\/jcm.01915-07","type":"journal-article","created":{"date-parts":[[2007,12,13]],"date-time":"2007-12-13T01:54:04Z","timestamp":1197510844000},"page":"515-521","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":199,"title":["<i>Candida krusei<\/i>\n            , a Multidrug-Resistant Opportunistic Fungal Pathogen: Geographic and Temporal Trends from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005"],"prefix":"10.1128","volume":"46","author":[{"given":"M. A.","family":"Pfaller","sequence":"first","affiliation":[{"name":"Departments of Pathology"}]},{"given":"D. J.","family":"Diekema","sequence":"additional","affiliation":[{"name":"Departments of Pathology"},{"name":"Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa"}]},{"given":"D. L.","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Giles Scientific, Inc., Santa Barbara, California"}]},{"given":"V. A.","family":"Newell","sequence":"additional","affiliation":[{"name":"Giles Scientific, Inc., Santa Barbara, California"}]},{"given":"E.","family":"Nagy","sequence":"additional","affiliation":[{"name":"University of Szeged, Szeged, Hungary"}]},{"given":"S.","family":"Dobiasova","sequence":"additional","affiliation":[{"name":"Zdravotni ustav se sidlem v Ostrave, Ostrava, Czech Republic"}]},{"given":"M.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"University of Texas Health Sciences Center, San Antonio, Texas"}]},{"given":"R.","family":"Barton","sequence":"additional","affiliation":[{"name":"Leeds General Infirmary, Leeds, United Kingdom"}]},{"given":"A.","family":"Veselov","sequence":"additional","affiliation":[{"name":"Institute of Antimicrobial Chemotherapy, Smolensk, Russia"}]},{"name":"the Global Antifungal Surveillance Group","sequence":"additional","affiliation":[]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.17.2659"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/513663"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.7.1856-1858.1996"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.7.2477-2482.2004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.3.917-921.2006"},{"key":"e_1_3_2_7_2","first-page":"619","volume":"23","year":"2004","unstructured":"Drago, M., M. M. Scaltrio, G. Morace, and the GISIA-2 Group. 2004. In vitro activity of voriconazole and other antifungal agents against clinical isolates of Candida glabrata and Candida krusei. Eur. J. Clin. Microbiol. Infect. Dis.23:619-624.","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.4.1213-1219.2003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.18.2267"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199305000-00002"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00148-06"},{"key":"e_1_3_2_12_2","first-page":"163","volume":"41","year":"2003","unstructured":"Hepburn, M. J., G. J. Pennick, D. A. Sutton, G. E. Crawford, and J. H. Jorgenson. 2003. Candida krusei renal cyst infection and measurement of amphotericin B levels in cystic fluid in a patient receiving AmBisome. Med. Mycol.41:163-165.","journal-title":"Med. 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