{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T13:57:37Z","timestamp":1774792657306,"version":"3.50.1"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Human adenoviruses (AdVs) typically cause mild illnesses in otherwise healthy hosts. We investigated a pediatric outbreak of acute respiratory infection with fatal outcomes that occurred in Lisbon, Portugal, in 2004. Biological specimens were collected from 83 children attending two nurseries, a kinesiotherapy clinic, and the household of a nanny. Adenovirus infection was confirmed in 48 children by PCR and virus isolation. Most (96%) isolates were classified as being of subspecies B1. Phylogenetic analysis of fiber and hexon gene sequences revealed that most infants were infected with AdV serotype 3 (AdV3) strains. Infants attending one nursery harbored a new recombinant strain containing an AdV serotype 7 hexon and serotype 3 fiber (AdV7\/3). Both the AdV3 and the AdV7\/3 strains caused fatal infections. Two different serotype 3 strains were circulating in Lisbon in 2004, and the new AdV7\/3 recombinant type originated from only one of those strains. These results demonstrate that recombination leads to the emergence of new adenovirus strains with epidemic and lethal potential.<\/jats:p>","DOI":"10.1128\/jcm.02019-09","type":"journal-article","created":{"date-parts":[[2010,2,11]],"date-time":"2010-02-11T05:29:40Z","timestamp":1265866180000},"page":"1391-1396","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["Outbreak of Acute Respiratory Infection among Infants in Lisbon, Portugal, Caused by Human Adenovirus Serotype 3 and a New 7\/3 Recombinant Strain"],"prefix":"10.1128","volume":"48","author":[{"given":"Helena","family":"Rebelo-de-Andrade","sequence":"first","affiliation":[{"name":"Instituto Nacional de Sau\u0301de I.P., Lisbon, Portugal"},{"name":"Centro de Investigac\u0327a\u0303o Interdisciplinar Egas Moniz (CiiEM), Instituto Superior de Cie\u0302ncias da Sau\u0301de Egas Moniz, Monte de Caparica, and Unidade dos Retrovi\u0301rus e Infecc\u0327o\u0303es Associadas, Centro de Patoge\u0301nese Molecular, Faculdade de Farma\u0301cia de Lisboa, Lisbon, Portugal"}]},{"given":"Cristiana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sau\u0301de I.P., Lisbon, Portugal"}]},{"given":"Marta","family":"Gi\u0301ria","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sau\u0301de I.P., Lisbon, Portugal"}]},{"given":"Ema","family":"Prude\u0302ncio","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sau\u0301de I.P., Lisbon, Portugal"}]},{"given":"Maria Joa\u0303o","family":"Brito","sequence":"additional","affiliation":[{"name":"Hospital de Fernando da Fonseca, Amadora, Portugal"}]},{"given":"Etelvina","family":"Cale\u0301","sequence":"additional","affiliation":[{"name":"Centro de Sau\u0301de da Amadora, Amadora, Portugal"}]},{"given":"Nuno","family":"Taveira","sequence":"additional","affiliation":[{"name":"Centro de Investigac\u0327a\u0303o Interdisciplinar Egas Moniz (CiiEM), Instituto Superior de Cie\u0302ncias da Sau\u0301de Egas Moniz, Monte de Caparica, and Unidade dos Retrovi\u0301rus e Infecc\u0327o\u0303es Associadas, Centro de Patoge\u0301nese Molecular, Faculdade de Farma\u0301cia de Lisboa, Lisbon, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.2.498-505.2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(00)00269-X"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.28.3.495-503.1990"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.3.1836-1844.1996"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.9.2331-2334.1994"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19497-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.20.12635-12642.2005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0803.010190"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.12.10260-10264.1998"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01316753"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02650-06"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199602)48:2<151::AID-JMV6>3.0.CO;2-8"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/518442"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0022"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2004.06.005"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.10.4594-4599.2003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/598521"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.83057-0"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.24.15265-15276.2005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.8.2984-2986.2001"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(83)90527-5"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2008.10.014"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31819075a6"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.1.140-145.2002"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/338471"},{"key":"e_1_3_2_27_2","first-page":"57","volume":"272","year":"2003","unstructured":"San Martin, C., and R. 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