{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:00:11Z","timestamp":1769767211732,"version":"3.49.0"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Candida parapsilosis<\/jats:italic>\n            , an emergent agent of nosocomial infections, was previously made up of a complex of three genetically distinct groups (groups I, II, and III). Recently, the\n            <jats:italic>C. parapsilosis<\/jats:italic>\n            groups have been renamed as distinct species:\n            <jats:italic>C. parapsilosis<\/jats:italic>\n            sensu stricto,\n            <jats:italic>C. orthopsilosis<\/jats:italic>\n            , and\n            <jats:italic>C. metapsilosis<\/jats:italic>\n            . In Portugal, no data pertaining to the distribution and antifungal susceptibility of these\n            <jats:italic>Candida<\/jats:italic>\n            species are yet available. In the present report, we describe the incidence and distribution of\n            <jats:italic>C. parapsilosis<\/jats:italic>\n            sensu stricto,\n            <jats:italic>C. orthopsilosis<\/jats:italic>\n            , and\n            <jats:italic>C. metapsilosis<\/jats:italic>\n            among 175 clinical and environmental isolates previously identified by conventional methods as\n            <jats:italic>C. parapsilosis<\/jats:italic>\n            . We also evaluated the in vitro susceptibilities of the isolates to fluconazole, voriconazole, posaconazole, amphotericin B, and two echinocandins, caspofungin and anidulafungin. Of the 175 isolates tested, 160 (91.4%) were identified as\n            <jats:italic>C. parapsilosis<\/jats:italic>\n            sensu stricto, 4 (2.3%) were identified as\n            <jats:italic>C. orthopsilosis<\/jats:italic>\n            , and 5 (2.9%) were identified as\n            <jats:italic>C. metapsilosis<\/jats:italic>\n            . Six isolates corresponded to species other than the\n            <jats:italic>C. parapsilosis<\/jats:italic>\n            group. Interestingly, all isolates from blood cultures corresponded to\n            <jats:italic>C. parapsilosis<\/jats:italic>\n            sensu stricto. Evaluation of the antifungal susceptibility profile showed that only nine (5.6%)\n            <jats:italic>C. parapsilosis<\/jats:italic>\n            sensu stricto strains were susceptible-dose dependent or resistant to fluconazole, and a single strain displayed a multiazole-resistant phenotype; two (1.3%)\n            <jats:italic>C. parapsilosis<\/jats:italic>\n            sensu stricto strains were amphotericin B resistant. All\n            <jats:italic>C. orthopsilosis<\/jats:italic>\n            and\n            <jats:italic>C. metapsilosis<\/jats:italic>\n            isolates were susceptible to azoles and amphotericin B. A high number of strains were nonsusceptible to the echinocandins (caspofungin and anidulafungin).\n          <\/jats:p>","DOI":"10.1128\/jcm.02379-08","type":"journal-article","created":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T01:35:55Z","timestamp":1244079355000},"page":"2392-2397","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":101,"title":["Prevalence, Distribution, and Antifungal Susceptibility Profiles of\n            <i>Candida parapsilosis<\/i>\n            ,\n            <i>C. orthopsilosis<\/i>\n            , and\n            <i>C. metapsilosis<\/i>\n            in a Tertiary Care Hospital"],"prefix":"10.1128","volume":"47","author":[{"given":"Ana P.","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto"}]},{"given":"Isabel M.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto"},{"name":"Cardiovascular Research &amp; Development Unit, Faculty of Medicine, University of Porto"}]},{"given":"Carmen","family":"Lisboa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto"}]},{"given":"Cida\u0301lia","family":"Pina-Vaz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto"},{"name":"Cardiovascular Research &amp; Development Unit, Faculty of Medicine, University of Porto"},{"name":"Department of Microbiology, Hospital S. Joa\u0303o"}]},{"given":"Aca\u0301cio G.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Porto"},{"name":"Cardiovascular Research &amp; Development Unit, Faculty of Medicine, University of Porto"},{"name":"Burn Unit and Department of Plastic and Reconstructive Surgery, Hospital S. 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