{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T09:44:29Z","timestamp":1767260669629},"reference-count":30,"publisher":"American Society for Microbiology","issue":"19","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Human immunodeficiency virus type 2 (HIV-2) infection, unlike HIV-1 infection, is normally characterized by low rates of CD4 depletion and low-to-undetectable viremia. We found that the frequency of Gag-specific CD4<jats:sup>+<\/jats:sup>T cells featured positive correlations with the expression of markers of CD4 activation and a negative correlation with peripheral blood mononuclear cell-associated proviral load in infection with HIV-2, in contrast with HIV-1. Moreover, HIV-2-infected individuals exhibited a greater ability to respond to HIV-1 Gag peptides (heterologous responses). Our data suggest a potential link between HIV-2-specific CD4 responses, immune activation, and viral control, which may in turn relate to the better prognosis associated with HIV-2 infection.<\/jats:p>","DOI":"10.1128\/jvi.01217-08","type":"journal-article","created":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T00:45:06Z","timestamp":1216860306000},"page":"9795-9799","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Gag-Specific CD4<sup>+<\/sup>T-Cell Frequency Is Inversely Correlated with Proviral Load and Directly Correlated with Immune Activation in Infection with Human Immunodeficiency Virus Type 2 (HIV-2) but Not HIV-1"],"prefix":"10.1128","volume":"82","author":[{"given":"Russell B.","family":"Foxall","sequence":"first","affiliation":[{"name":"Unidade de Imunologia Cli\u0301nica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Catarina S.","family":"Cortesa\u0303o","sequence":"additional","affiliation":[{"name":"Unidade de Imunologia Cli\u0301nica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Adriana S.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Unidade de Imunologia Cli\u0301nica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Rui S.","family":"Soares","sequence":"additional","affiliation":[{"name":"Unidade de Imunologia Cli\u0301nica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Rui M. M.","family":"Victorino","sequence":"additional","affiliation":[{"name":"Unidade de Imunologia Cli\u0301nica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"},{"name":"Cli\u0301nica Universita\u0301ria de Medicina 2, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Ana E.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Unidade de Imunologia Cli\u0301nica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. 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