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Here we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion. Moreover, HIV-2 proviral DNA was essentially restricted to memory-effector CD4, suggesting that this is the main target for HIV-2. Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability.<\/jats:p>","DOI":"10.1128\/jvi.01557-06","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T23:43:39Z","timestamp":1164671019000},"page":"12425-12429","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Increased Frequency of Circulating CCR5<sup>+<\/sup>CD4<sup>+<\/sup>T Cells in Human Immunodeficiency Virus Type 2 Infection"],"prefix":"10.1128","volume":"80","author":[{"given":"Rui","family":"Soares","sequence":"first","affiliation":[{"name":"Unidade de Imunologia Cli\u0301nica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. 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