{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:51:31Z","timestamp":1770436291171,"version":"3.49.0"},"reference-count":85,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The begomoviruses are the largest and most economically important group of plant viruses transmitted exclusively by the whitefly\n            <jats:italic>Bemisia tabaci<\/jats:italic>\n            in a circulative, persistent manner. The circulation of the viruses within the insect vectors involves complex interactions between virus and vector components; however, the molecular mechanisms of these interactions remain largely unknown. Here we investigated the transcriptional response of the invasive\n            <jats:italic>B. tabaci<\/jats:italic>\n            Middle East-Asia Minor 1 species to\n            <jats:italic>Tomato yellow leaf curl China virus<\/jats:italic>\n            (TYLCCNV) using Illumina sequencing technology. Results showed that 1,606 genes involved in 157 biochemical pathways were differentially expressed in the viruliferous whiteflies. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that TYLCCNV can perturb the cell cycle and primary metabolism in the whitefly, which explains the negative effect of this virus on the longevity and fecundity of\n            <jats:italic>B. tabaci<\/jats:italic>\n            . Our data also demonstrated that TYLCCNV can activate whitefly immune responses, such as autophagy and antimicrobial peptide production, which might lead to a gradual decrease of viral particles within the body of the viruliferous whitefly. Furthermore, PCR results showed that TYLCCNV can invade the ovary and fat body tissues of the whitefly, and Lysotracker and Western blot analyses revealed that the invasion of TYLCCNV induced autophagy in both the ovary and fat body tissues. Surprisingly, TYLCCNV also suppressed the whitefly immune responses by downregulating the expression of genes involved in Toll-like signaling and mitogen-activated protein kinase (MAPK) pathways. Taken together, these results reveal the relationship of coevolved adaptations between begomoviruses and whiteflies and will provide a road map for future investigations into the complex interactions between plant viruses and their insect vectors.\n          <\/jats:p>","DOI":"10.1128\/jvi.02507-10","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T02:25:18Z","timestamp":1296095118000},"page":"3330-3340","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":155,"title":["Global Analysis of the Transcriptional Response of Whitefly to\n            <i>Tomato Yellow Leaf Curl China Virus<\/i>\n            Reveals the Relationship of Coevolved Adaptations"],"prefix":"10.1128","volume":"85","author":[{"given":"Jun-Bo","family":"Luan","sequence":"first","affiliation":[{"name":"Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China"}]},{"given":"Jun-Min","family":"Li","sequence":"additional","affiliation":[{"name":"Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China"}]},{"given":"Ne\u0301lia","family":"Varela","sequence":"additional","affiliation":[{"name":"Department of Crop Protection, Centre UdL-IRTA, University of Lleida, Av. Alcalde Rovira Roure, 191, 25198 Lleida, Spain"}]},{"given":"Yong-Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China"}]},{"given":"Fang-Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China"}]},{"given":"Yan-Yuan","family":"Bao","sequence":"additional","affiliation":[{"name":"Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China"}]},{"given":"Chuan-Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China"}]},{"given":"Shu-Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China"}]},{"given":"Xiao-Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310029, China"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.108.121038"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7.10.986"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.28.1.295"},{"key":"e_1_3_3_5_2","first-page":"911","volume":"8","year":"2008","unstructured":"Bowie, A. 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