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The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the\n            <jats:italic>env<\/jats:italic>\n            gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter generation time or higher mutation rate of HIV-2. Thus, the lower virulence of HIV-2 does not appear to translate into a lower rate of evolution.\n          <\/jats:p>","DOI":"10.1128\/jvi.02548-09","type":"journal-article","created":{"date-parts":[[2010,5,13]],"date-time":"2010-05-13T01:37:29Z","timestamp":1273714649000},"page":"7412-7415","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["HIV-2 Genetic Evolution in Patients with Advanced Disease Is Faster than That in Matched HIV-1 Patients"],"prefix":"10.1128","volume":"84","author":[{"given":"Helena","family":"Skar","sequence":"first","affiliation":[{"name":"Department of Virology, Swedish Institute for Infectious Disease Control, Solna, Sweden"},{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden"},{"name":"Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New 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