{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T03:02:42Z","timestamp":1771902162109,"version":"3.50.1"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen (\n            <jats:sup>1<\/jats:sup>\n            O\n            <jats:sub>2<\/jats:sub>\n            ), similar to the mechanistic paradigm established for LJ001, a chemically unrelated class of Broad-SAVE. Photosensitization of viral membranes is a common mechanism that underlies these Broad-SAVE.\n          <\/jats:p>","DOI":"10.1128\/jvi.02907-13","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T04:25:20Z","timestamp":1385612720000},"page":"1849-1853","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":68,"title":["The Rigid Amphipathic Fusion Inhibitor dUY11 Acts through Photosensitization of Viruses"],"prefix":"10.1128","volume":"88","author":[{"given":"Frederic","family":"Vigant","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA"}]},{"given":"Axel","family":"Hollmann","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Jihye","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California, USA"}]},{"given":"Nuno C.","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Michael E.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California, USA"}]},{"given":"Benhur","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, 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