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It is phylogenetically assigned to the Taphrinomycotina subphylum, which includes the fission yeast and the mammalian pathogens of the genus\n            <jats:italic>Pneumocystis<\/jats:italic>\n            . We describe here the genome of\n            <jats:italic>T.\u00a0deformans<\/jats:italic>\n            in the light of its dual plant-saprophytic\/plant-parasitic lifestyle. The 13.3-Mb genome contains few identifiable repeated elements (ca. 1.5%) and a relatively high GC content (49.5%). A total of 5,735 protein-coding genes were identified, among which 83% share similarities with other fungi. Adaptation to the plant host seems reflected in the genome, since the genome carries genes involved in plant cell wall degradation (e.g., cellulases and cutinases), secondary metabolism, the hallmark glyoxylate cycle, detoxification, and sterol biosynthesis, as well as genes involved in the biosynthesis of plant hormones. Genes involved in lipid metabolism may play a role in its virulence. Several locus candidates for putative\n            <jats:italic>MAT<\/jats:italic>\n            cassettes and sex-related genes akin to those of\n            <jats:named-content content-type=\"genus-species\">Schizosaccharomyces pombe<\/jats:named-content>\n            were identified. A mating-type-switching mechanism similar to that found in ascomycetous yeasts could be in effect. Taken together, the findings are consistent with the alternate saprophytic and parasitic-pathogenic lifestyles of\n            <jats:italic>T.\u00a0deformans<\/jats:italic>\n            .\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>IMPORTANCE<\/jats:bold>\n            Peach leaf curl is\u00a0an\u00a0important plant disease\u00a0which causes significant losses\u00a0of\u00a0fruit\u00a0production. We report here the genome sequence\u00a0of the causative agent of the disease, the fungus\u00a0\n            <jats:italic>Taphrina deformans<\/jats:italic>\n            . The genome carries characteristic genes\u00a0that are important for\u00a0the plant infection process. These include (i) proteases\u00a0that allow degradation of the plant\u00a0tissues;\u00a0(ii) secondary metabolites which are products favoring\u00a0interaction of the fungus with the environment, including the host; (iii)\u00a0hormones\u00a0that are responsible for the symptom of severely distorted\u00a0leaves on the host; and\u00a0(iv) drug detoxification enzymes\u00a0that\u00a0confer resistance\u00a0to fungicides. The availability of the genome allows the design of new drug targets as well as the elaboration of specific management strategies\u00a0to fight the disease.\n          <\/jats:p>","DOI":"10.1128\/mbio.00055-13","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T13:08:28Z","timestamp":1367413708000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":92,"title":["Genome Sequencing of the Plant Pathogen\n            <i>Taphrina deformans<\/i>\n            , the Causal Agent of Peach Leaf Curl"],"prefix":"10.1128","volume":"4","author":[{"given":"Ousmane H.","family":"Ciss\u00e9","sequence":"first","affiliation":[{"name":"Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"},{"name":"Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland"}]},{"given":"Jo\u00e3o M. G. C. F.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Centro de Recursos Microbiol\u00f3gicos (CREM), Departamento de Ci\u00eancias da Vida, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal"}]},{"given":"\u00c1lvaro","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Centro de Recursos Microbiol\u00f3gicos (CREM), Departamento de Ci\u00eancias da Vida, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal"}]},{"given":"Ajay Anand","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Plant Biology, Department of Biosciences, University of Helsinki, Helsinki, Finland"}]},{"given":"Jarkko","family":"Saloj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Division of Plant Biology, Department of Biosciences, University of Helsinki, Helsinki, Finland"}]},{"given":"Kirk","family":"Overmyer","sequence":"additional","affiliation":[{"name":"Division of Plant Biology, Department of Biosciences, University of Helsinki, Helsinki, Finland"}]},{"given":"Philippe M.","family":"Hauser","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}]},{"given":"Marco","family":"Pagni","sequence":"additional","affiliation":[{"name":"Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Compendium of stone fruit diseases","author":"Ogawa JM","year":"1995","unstructured":"OgawaJM ZehrEI BirdGW RitchieK UriuK UyemotoJK . 1995. 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