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        <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract. The etiology of IBD remains elusive, but the disease is suggested to arise from the interaction of environmental and genetic factors that trigger inadequate immune responses and inflammation in the intestine. The gut microbiome majorly contributes to disease as an environmental variable, and although some causative bacteria are identified, little is known about which specific members of the microbiome aid in the intestinal epithelial barrier function to protect from disease. While chemically inducing colitis in mice from two distinct animal facilities, we serendipitously found that mice in one facility showed remarkable resistance to disease development, which was associated with increased markers of epithelial barrier integrity. Importantly, we show that\n              <jats:italic>Akkermansia muciniphila<\/jats:italic>\n              and\n              <jats:italic>Parabacteroides distasonis<\/jats:italic>\n              were significantly increased in the microbiota of resistant mice. To causally connect these microbes to protection against disease, we colonized susceptible mice with the two bacterial species. Our results demonstrate that\n              <jats:italic>A. muciniphila<\/jats:italic>\n              and\n              <jats:italic>P<\/jats:italic>\n              .\n              <jats:italic>distasonis<\/jats:italic>\n              synergistically drive a protective effect in both acute and chronic models of colitis by boosting the frequency of type 3 innate lymphoid cells in the colon and by improving gut epithelial integrity. Altogether, our work reveals a combined effort of commensal microbes in offering protection against severe intestinal inflammation by shaping gut immunity and by enhancing intestinal epithelial barrier stability. Our study highlights the beneficial role of gut bacteria in dictating intestinal homeostasis, which is an important step toward employing microbiome-driven therapeutic approaches for IBD clinical management.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>\n              The contribution of the gut microbiome to the balance between homeostasis and inflammation is widely known. Nevertheless, the etiology of inflammatory bowel disease, which is known to be influenced by genetics, immune response, and environmental cues, remains unclear. Unlocking novel players involved in the dictation of a protective gut, namely, in the microbiota component, is therefore crucial to develop novel strategies to tackle IBD. Herein, we revealed a synergistic interaction between two commensal bacterial strains,\n              <jats:italic>Akkermansia muciniphila<\/jats:italic>\n              and\n              <jats:italic>Parabacteroides distasonis<\/jats:italic>\n              , which induce protection against both acute and chronic models of colitis induction, by enhancing epithelial barrier integrity and promoting group 3 innate lymphoid cells in the colonic mucosa. This study provides a novel insight on how commensal bacteria can beneficially act to promote intestinal homeostasis, which may open new avenues toward the use of microbiome-derived strategies to tackle IBD.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/mbio.00078-24","type":"journal-article","created":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T17:25:16Z","timestamp":1710696316000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":54,"title":["<i>Akkermansia muciniphila<\/i>\n            and\n            <i>Parabacteroides distasonis<\/i>\n            synergistically protect from colitis by promoting ILC3 in the gut"],"prefix":"10.1128","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-7378","authenticated-orcid":false,"given":"Joana","family":"Gaifem","sequence":"first","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, 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