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The high levels of antibiotic resistance detected worldwide threaten our ability to combat infections and other 20th-century medical achievements, namely, organ transplantation or cancer chemotherapy. We have identified and characterized a unique family of enzymes capable of phosphorylating glucosamine to glucosamine-6-phosphate, a crucial molecule directly involved in the activation of antibiotic production pathways in\n                    <jats:italic>Actinobacteria<\/jats:italic>\n                    , nature\u2019s main source of antimicrobials. The consensus sequence identified for these glucosamine kinases will help establish a molecular fingerprint to reveal yet-uncharacterized sequences in antibiotic producers, which should have an important impact in biotechnological and biomedical applications, including the enhancement and optimization of antibiotic production.\n                  <\/jats:p>","DOI":"10.1128\/mbio.00239-19","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T10:01:24Z","timestamp":1557741684000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Molecular Fingerprints for a Novel Enzyme Family in\n                    <i>Actinobacteria<\/i>\n                    with Glucosamine Kinase Activity"],"prefix":"10.1128","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2565-6239","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Manso","sequence":"first","affiliation":[{"name":"IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal"},{"name":"i3S-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-9233","authenticated-orcid":false,"given":"Daniela","family":"Nunes-Costa","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal"},{"name":"PhD Program in Experimental Biology and Biomedicine (PDBEB), University of Coimbra, Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7698-1170","authenticated-orcid":false,"given":"Sandra","family":"Macedo-Ribeiro","sequence":"additional","affiliation":[{"name":"IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal"},{"name":"i3S-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8938-7560","authenticated-orcid":false,"given":"Nuno","family":"Empadinhas","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal"},{"name":"IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0969-5438","authenticated-orcid":false,"given":"Pedro Jos\u00e9 Barbosa","family":"Pereira","sequence":"additional","affiliation":[{"name":"IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal"},{"name":"i3S-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Porto, Portugal"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4137\/PMC.S14459"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17042"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7NP00026J"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-145-9-2183"},{"key":"e_1_3_3_6_2","first-page":"889","volume-title":"The prokaryotes: actinobacteria.","author":"K\u00e4mpfer P","year":"2014","unstructured":"K\u00e4mpfer P, Glaeser SP, Parkes L, van Keulen G, Dyson P. 2014. 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