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Two decreasing O\n                    <jats:sub>2<\/jats:sub>\n                    gradients are observed, a longitudinal one from the small to the large intestine and a second one from the intestinal epithelium toward the colon lumen. Thus, O\n                    <jats:sub>2<\/jats:sub>\n                    concentration fluctuations within the gastrointestinal tract are a challenge for anaerobic bacteria such as\n                    <jats:named-content content-type=\"genus-species\">C. difficile<\/jats:named-content>\n                    . This enteropathogen has developed efficient strategies to detoxify O\n                    <jats:sub>2<\/jats:sub>\n                    . In this work, we identified reverse rubrerythrins and flavodiiron proteins as key actors for O\n                    <jats:sub>2<\/jats:sub>\n                    tolerance in\n                    <jats:named-content content-type=\"genus-species\">C. difficile<\/jats:named-content>\n                    . These enzymes are responsible for the reduction of O\n                    <jats:sub>2<\/jats:sub>\n                    protecting\n                    <jats:named-content content-type=\"genus-species\">C. difficile<\/jats:named-content>\n                    vegetative cells from associated damages. Original and complex detoxification pathways involving O\n                    <jats:sub>2<\/jats:sub>\n                    -reductases are crucial in the ability of\n                    <jats:named-content content-type=\"genus-species\">C. difficile<\/jats:named-content>\n                    to tolerate O\n                    <jats:sub>2<\/jats:sub>\n                    and survive to O\n                    <jats:sub>2<\/jats:sub>\n                    concentrations encountered in the gastrointestinal tract.\n                  <\/jats:p>","DOI":"10.1128\/mbio.01559-20","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T09:23:16Z","timestamp":1599470596000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["How the Anaerobic Enteropathogen\n                    <i>Clostridioides difficile<\/i>\n                    Tolerates Low O\n                    <sub>2<\/sub>\n          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