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The nascent field of phage therapy was adversely affected by inadequately controlled trials and the discovery of antibiotics. Although the study of phages as anti-infective agents slowed, phages played an important role in the development of molecular biology. In recent years, the increase in multidrug-resistant bacteria has renewed interest in the use of phages as antimicrobial agents. With the wide array of possibilities offered by genetic engineering, these bacterial viruses are being modified to precisely control and detect bacteria and to serve as new sources of antibacterials. In applications that go beyond their antimicrobial activity, phages are also being developed as vehicles for drug delivery and vaccines, as well as for the assembly of new materials. This review highlights advances in techniques used to engineer phages for all of these purposes and discusses existing challenges and opportunities for future work.<\/jats:p>","DOI":"10.1128\/mmbr.00069-15","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T04:06:21Z","timestamp":1464840381000},"page":"523-543","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":372,"title":["Genetically Engineered Phages: a Review of Advances over the Last Decade"],"prefix":"10.1128","volume":"80","author":[{"given":"Diana P.","family":"Pires","sequence":"first","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"},{"name":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"},{"name":"Centre of Biological Engineering, University of Minho, Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1273-0142","authenticated-orcid":false,"given":"Sara","family":"Cleto","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"},{"name":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"}]},{"given":"Sanna","family":"Sillankorva","sequence":"additional","affiliation":[{"name":"Centre of Biological Engineering, University of Minho, Braga, Portugal"}]},{"given":"Joana","family":"Azeredo","sequence":"additional","affiliation":[{"name":"Centre of Biological Engineering, University of Minho, Braga, Portugal"}]},{"given":"Timothy K.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"},{"name":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)20383-3"},{"key":"e_1_3_2_3_2","first-page":"373","article-title":"Sur un microbe invisible antagoniste des bacilles dysent\u00e9riques","volume":"165","author":"d'H\u00e9relle F","year":"1917","unstructured":"d'H\u00e9relle F. 1917. 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