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Thus, understanding of the molecular mechanisms of drug resistance is of crucial interest for the medical community. Here we investigated the role of regulated protein mistranslation, a characteristic mechanism used by\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            to diversify its proteome, in the evolution of fluconazole resistance. Such codon ambiguity is usually considered highly deleterious, yet recent studies found that mistranslation can boost adaptation in stressful environments. Our data reveal that CUG ambiguity diversifies the genome in multiple ways and that the full spectrum of drug resistance mechanisms in\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            goes beyond the traditional pathways that either regulate drug efflux or alter the interactions of drugs with their targets. The present work opens new avenues by which to understand the molecular and genetic basis of microbial drug resistance.\n          <\/jats:p>","DOI":"10.1128\/msphere.00167-17","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T00:40:21Z","timestamp":1502325621000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans"],"prefix":"10.1128","volume":"2","author":[{"given":"Tobias","family":"Weil","sequence":"first","affiliation":[{"name":"Department of Medical Sciences &amp; Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal"},{"name":"Research and Innovation Centre, Fondazione E. 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