{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T20:40:21Z","timestamp":1772656821253,"version":"3.50.1"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["15\/16990-5"],"award-info":[{"award-number":["15\/16990-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["16\/03322-7"],"award-info":[{"award-number":["16\/03322-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["16\/25167-3"],"award-info":[{"award-number":["16\/25167-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["15\/16999-2"],"award-info":[{"award-number":["15\/16999-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,4,24]]},"abstract":"<jats:p>\n                    Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. Although the immune mechanisms to control PCM are still not fully understood, several events of the host innate and adaptive immunity are crucial to determine the progress of the infection. Mammalian \u03b2-galactoside-binding protein galectin-3 (Gal-3) plays significant roles during microbial infections and has been studied for its immunomodulatory roles, but it can also have direct antimicrobial effects. We asked whether this protein plays a role in\n                    <jats:named-content content-type=\"genus-species\">Paracoccidioides brasiliensis<\/jats:named-content>\n                    . We report herein that Gal-3 indeed has direct effects on the fungal pathogen, inhibiting fungal growth and reducing extracellular vesicle stability. Our results suggest a direct role for Gal-3 in\n                    <jats:italic>P. brasiliensis<\/jats:italic>\n                    infection, with beneficial effects for the mammalian host.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00209-19","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T06:57:12Z","timestamp":1556002632000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Galectin-3 Inhibits Paracoccidioides brasiliensis Growth and Impacts Paracoccidioidomycosis through Multiple Mechanisms"],"prefix":"10.1128","volume":"4","author":[{"given":"Otavio","family":"Hatanaka","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil"}]},{"given":"Caroline Patini","family":"Rezende","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil"}]},{"given":"Pedro","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil"}]},{"given":"Fabr\u00edcio","family":"Freitas Fernandes","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil"}]},{"given":"Patr\u00edcia Kellen Martins","family":"Oliveira Brito","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil"}]},{"given":"Roberto","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil"}]},{"given":"Carolina","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom"},{"name":"Medical Research Council Centre for Medical Mycology, University of Aberdeen, Aberdeen, United Kingdom"}]},{"given":"Maria Cristina","family":"Roque-Barreira","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-9167","authenticated-orcid":false,"given":"Arturo","family":"Casadevall","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3782-3698","authenticated-orcid":false,"given":"Fausto","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00214"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2011.577821"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.6.2.89"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.39.3.233.241"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0230-2017"},{"key":"e_1_3_2_7_2","first-page":"115","article-title":"Host-parasite relationship in paracoccidioidomycosis","volume":"5","author":"Franco M","year":"1993","unstructured":"Franco M, Peracoli MT, Soares A, Montenegro R, Mendes RP, Meira DA. 1993. Host-parasite relationship in paracoccidioidomycosis. Curr Top Med Mycol 5:115\u2013149.","journal-title":"Curr Top Med Mycol"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821987000200012"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02292-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3480"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14095"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00370-07"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01171-09"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep35867"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12374"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02126-7"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02343"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2012.01757.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2146"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/yea.2983"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00537-17"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389202917666151116212705"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2013.770607"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202122"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004519"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1154-7_24"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080500"},{"key":"e_1_3_2_28_2","first-page":"1016","article-title":"Expression and function of galectin-3, a beta-galactoside-binding lectin, in human monocytes and macrophages","volume":"147","author":"Liu FT","year":"1995","unstructured":"Liu FT, Hsu DK, Zuberi RI, Kuwabara I, Chi EY, Henderson WR, Jr. 1995. Expression and function of galectin-3, a beta-galactoside-binding lectin, in human monocytes and macrophages. Am J Pathol 147:1016\u20131028.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17592"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.18.7324"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00284"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01998"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05131.x"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020379"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.263"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10895-009-0522-7"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(02)00313-6"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.3.1902"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737986"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04063-5"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535370215593826"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.06.017"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm801077j"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64975-9"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00683967"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029216"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00227-10"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00209-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00209-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T23:15:30Z","timestamp":1646694930000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00209-19"}},"subtitle":[],"editor":[{"given":"Aaron P.","family":"Mitchell","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4,24]]}},"alternative-id":["10.1128\/mSphere.00209-19"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00209-19","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/557918","asserted-by":"object"}]},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,24]]},"assertion":[{"value":"2019-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00209-19"}}