{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:21:56Z","timestamp":1775060516984,"version":"3.50.1"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"MCTI | Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302372\/2014-8"],"award-info":[{"award-number":["302372\/2014-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/07870-9"],"award-info":[{"award-number":["2016\/07870-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"EC | European Regional Development Fund","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000013"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000013"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,8,28]]},"abstract":"<jats:p>\n            Invasive aspergillosis (IA) has emerged as one of the most common life-threatening fungal diseases in immunocompromised patients, with mortality rates as high as 90%. Systemic fungal infections such as IA are usually treated with triazoles; however, epidemiological research has shown that the prevalence of azole-resistant\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            isolates has increased significantly over the last decade. There is very little information about the importance of genomic stability for\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            population structure, azole resistance, and virulence. Here, we decided to investigate whether the mismatch repair system could influence\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            azole resistance and virulence, focusing on one of the components of this system,\n            <jats:italic>MSH2<\/jats:italic>\n            . Although the mutation frequency of\n            <jats:italic>mshA<\/jats:italic>\n            (the\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            <jats:italic>MSH2<\/jats:italic>\n            homologue) is low in environmental and clinical isolates, our results indicate that loss of\n            <jats:italic>mshA<\/jats:italic>\n            function can provide increased azole resistance and virulence when selected for. These results demonstrate the importance of genetic instability in\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            as a possible mechanism of evolving azole resistance and establishing fitness in the host.\n          <\/jats:p>","DOI":"10.1128\/msphere.00416-19","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T13:23:24Z","timestamp":1565097804000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["The Aspergillus fumigatus Mismatch Repair\n            <i>MSH2<\/i>\n            Homolog Is Important for Virulence and Azole Resistance"],"prefix":"10.1128","volume":"4","author":[{"given":"Thaila Fernanda","family":"dos Reis","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}]},{"given":"Lilian Pereira","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}]},{"given":"Patr\u00edcia Alves","family":"de Castro","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}]},{"given":"Rafaela Andrade","family":"do Carmo","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}]},{"given":"Marjorie Mendes","family":"Marini","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}]},{"given":"Jos\u00e9 Franco","family":"da Silveira","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}]},{"given":"Beatriz Henriques","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"}]},{"given":"Fernando","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"}]},{"given":"Abigail Lee","family":"Lind","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University, 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