{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:31:22Z","timestamp":1772163082872,"version":"3.50.1"},"reference-count":63,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000052","name":"HHS | NIH | NIH Office of the Director","doi-asserted-by":"publisher","award":["5R01HL059842"],"award-info":[{"award-number":["5R01HL059842"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,8,28]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus neoformans<\/jats:named-content>\n                    causes an estimated 181, 000 deaths each year, mostly associated with untreated HIV\/AIDS.\n                    <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n                    has a ubiquitous worldwide distribution. Humans become infected from exposure to environmental sources, after which the fungus lays dormant within the human body. Upon AIDS-induced immunosuppression or therapy-induced immunosuppression (required for organ transplant recipients or those suffering from autoimmune disorders), cryptococcal disease reactivates and causes life-threatening meningitis and pneumonia. This study showed that upon contact with the host,\n                    <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n                    can quickly (a few hours) reach the host brain and also colonizes the nose of infected animals. Therefore, this work paves the way to better knowledge of how\n                    <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n                    travels through the host body. Understanding how\n                    <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n                    infects, disseminates, and survives within the host is critically required so that we can prevent infections and the disease caused by this deadly fungus.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00483-19","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T09:23:24Z","timestamp":1565083404000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Intranasal Inoculation of Cryptococcus neoformans in Mice Produces Nasal Infection with Rapid Brain Dissemination"],"prefix":"10.1128","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-3031","authenticated-orcid":false,"given":"Carolina","family":"Coelho","sequence":"first","affiliation":[{"name":"W. 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