{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:57:41Z","timestamp":1784357861470,"version":"3.55.0"},"reference-count":23,"publisher":"Pleiades Publishing Ltd","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochemistry Moscow"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1134\/s0006297920090084","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T17:24:52Z","timestamp":1600795492000},"page":"1082-1092","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrastructure of Hepatocytes from Laboratory Mice Fed a Standard Dry Laboratory Animal Diet"],"prefix":"10.1134","volume":"85","author":[{"given":"V. B.","family":"Vays","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. M.","family":"Vangeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. A.","family":"Averina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Lovat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. E.","family":"Bakeeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"137","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"2064_CR1","first-page":"439","volume":"11","author":"A. J. Dalton","year":"1950","unstructured":"Dalton, A. J., Kahler, H., Striebich, M. J., and Lloyd, B. (1950) Finer structure of hepatic, intestinal and renal cells of the mouse as revealed by the electron microscope, J. Natl. Cancer Inst., 11, 439-461.","journal-title":"J. Natl. Cancer Inst."},{"key":"2064_CR2","first-page":"1475","volume":"15","author":"D. W. Fawcett","year":"1955","unstructured":"Fawcett, D. W. (1955) Observations on the cytology and electron microscopy of hepatic cells, J. Natl. Cancer Inst., 15, 1475-1503.","journal-title":"J. Natl. Cancer Inst."},{"key":"2064_CR3","first-page":"691","volume":"46","author":"C. Bruni","year":"1965","unstructured":"Bruni, C., and Porter, K. R. (1965) The fine structure of the parenchymal cell of the normal rat liver: I. General observations, Am. J. Pathol., 46, 691-755.","journal-title":"Am. J. Pathol."},{"key":"2064_CR4","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1177\/14.3.215","volume":"14","author":"A. L. Jones","year":"1966","unstructured":"Jones, A. L., and Fawcett, D. W. (1966) Hypertrophy of the agranular endoplasmic reticulum in hamster liver induced by phenobarbital (with a review on the functions of this organelle in liver), J. Histochem. Cytochem., 14, 215-232.","journal-title":"J. Histochem. Cytochem."},{"key":"2064_CR5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1749-6632.1965.tb12247.x","volume":"123","author":"H. Remmer","year":"1965","unstructured":"Remmer, H., and Merker, H. J. (1965) Effect of drugs on the formation of smooth endoplasmic reticulum and drug-metabolizing enzymes, Ann. NY Acad. Sci., 123, 79-97.","journal-title":"Ann. NY Acad. Sci."},{"key":"2064_CR6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/BF00320181","volume":"58","author":"J. W. Steiner","year":"1962","unstructured":"Steiner, J. W., Carruthers, J. S., and Kalifat, S. R. (1962) Observations on the fine structure of rat liver cells in extrahepatic cholestasis, Z. Zellforsch. Mikrosk. Anat., 58, 141-159.","journal-title":"Z. Zellforsch. Mikrosk. Anat."},{"key":"2064_CR7","first-page":"307","volume":"46","author":"R. L. Wood","year":"1965","unstructured":"Wood, R. L. (1965) The fine structure of hepatic cells in chronic ethionine poisoning and during recovery, Am. J. Pathol., 46, 307-330.","journal-title":"Am. J. Pathol."},{"key":"2064_CR8","first-page":"409","volume":"46","author":"R. B. Arhelger","year":"1965","unstructured":"Arhelger, R. B., Broom, J. S., and Boler, R. K. (1965) Ultrastructural hepatic alterations following tannic acid administration to rabbits, Am. J. Pathol., 46, 409-434.","journal-title":"Am. J. Pathol."},{"key":"2064_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5114\/ceh.2017.68287","volume":"3","author":"A. Wieczorek","year":"2017","unstructured":"Wieczorek, A., St\u0119pie\u0144, P. M., Zar\u0119bska-Michaluk, D., Kryczka, W., Pabjan, P., and Kr\u00f3l, T. (2017) Megamitochondria formation in hepatocytes of patient with chronic hepatitis C \u2013 a case report, Clin. Exp. Hepatol., 3, 169-175.","journal-title":"Clin. Exp. Hepatol."},{"key":"2064_CR10","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/S0006-291X(03)00884-2","volume":"305","author":"V. Falc\u00f3n","year":"2003","unstructured":"Falc\u00f3n, V., Acosta-Rivero, N., Chinea, G., Gavilondo, J., de la Rosa, M. C., Men\u00e9ndez, I., Due\u00f1as-Carrera, S., Vi\u00f1a, A., Garc\u00eda, W., Gra, B., Noa, M., Reytor, E., Barcel\u00f3, M. T., Alvarez, F., and Morales-Grillo, J. (2003) Ultrastructural evidences of HCV infection in hepatocytes of chronically HCV-infected patients, Biochem. Biophys. Res. Commun., 305, 1085-1090.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2064_CR11","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.3748\/wjg.v20.i7.1768","volume":"20","author":"X. Q. Zhang","year":"2014","unstructured":"Zhang, X. Q., Xu, C. F., Yu, C. H., Chen, W. X., and Li, Y. M. (2014) Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease, World J. Gastroenterol., 20, 1768-1776.","journal-title":"World J. Gastroenterol."},{"key":"2064_CR12","doi-asserted-by":"publisher","first-page":"3093","DOI":"10.2337\/dc07-1088","volume":"30","author":"A. M. Cali","year":"2007","unstructured":"Cali, A. M., Zern, T. L., Taksali, S. E., de Oliveira, A. M., Dufour, S., Otvos, J. D., and Caprio, S. (2007) Intrahepatic fat accumulation and alterations in lipoprotein composition in obese adolescents: a perfect proatherogenic state, Diabetes Care, 30, 3093-3098.","journal-title":"Diabetes Care"},{"key":"2064_CR13","doi-asserted-by":"publisher","first-page":"783976","DOI":"10.1155\/2011\/783976","volume":"2011","author":"K. Fon Tacer","year":"2011","unstructured":"Fon Tacer, K., and Rozman, D. (2011) Nonalcoholic fatty liver disease: focus on lipoprotein and lipid deregulation, J. Lipids, 2011, 783976.","journal-title":"J. Lipids"},{"key":"2064_CR14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1080\/01913123.2017.1422581","volume":"42","author":"M. A. Dallak","year":"2018","unstructured":"Dallak, M. A., Bin-Jaliah, I., Albawardi, A., Haidara, M. A., Sakr, H. F., Eid, R. A., Hassan, W. N., and Al-Ani, B. (2018) Swim exercise training ameliorates hepatocyte ultrastructural alterations in rats fed on a high fat and sugar diet, Ultrastruct. Pathol., 42, 155-161.","journal-title":"Ultrastruct. Pathol."},{"key":"2064_CR15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00418-019-01823-2","volume":"153","author":"S. M. Abo El-Khair","year":"2020","unstructured":"Abo El-Khair, S. M., Ghoneim, F. M., Shabaan, D. A., and Elsamanoudy, A. Z. (2020) Molecular and ultrastructure study of endoplasmic reticulum stress in hepatic steatosis: role of hepatocyte nuclear factor 4\u03b1 and inflammatory mediators, Histochem. Cell Biol., 153, 49-62.","journal-title":"Histochem. Cell Biol."},{"key":"2064_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.mce.2018.03.013","volume":"474","author":"F. M. Silva-Veiga","year":"2018","unstructured":"Silva-Veiga, F. M., Rachid, T. L., de Oliveira, L., Graus-Nunes, F., Mandarim-de-Lacerda, C. A., and Souza-Mello, V. (2018) GW0742 (PPAR-beta agonist) attenuates hepatic endoplasmic reticulum stress by improving hepatic energy metabolism in high-fat diet fed mice, Mol. Cell Endocrinol., 474, 227-237.","journal-title":"Mol. Cell Endocrinol."},{"key":"2064_CR17","unstructured":"GOST R 50258-92 (1992) Combined Full-Rationed Feeds for Laboratory Animals, Technical Conditions, Standard Izd. (in Russian)."},{"key":"2064_CR18","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1083\/jcb.17.1.208","volume":"17","author":"E. S. Reynolds","year":"1963","unstructured":"Reynolds, E. S. (1963) The use of lead citrate at high pH as an electron-opaque stain in electron microscopy, J. Cell Biol., 17, 208-212.","journal-title":"J. Cell Biol."},{"key":"2064_CR19","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1590\/S1516-31802011000400004","volume":"129","author":"G. H. Silva","year":"2011","unstructured":"Silva, G. H., Hessel, G., Coelho, K. I., and Escanhoela, C. A. (2011) Steatosis of indeterminate cause in a pediatric group: is it a primary mitochondrial hepatopathy? Sao Paulo Med. J., 129, 217-223.","journal-title":"Sao Paulo Med. J."},{"key":"2064_CR20","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.freeradbiomed.2009.07.016","volume":"47","author":"M. Aragno","year":"2009","unstructured":"Aragno, M., Tomasinelli, C. E., Vercellinatto, I., Catalano, M. G., Collino, M., Fantozzi, R., Danni, O., and Boccuzzi, G. (2009) SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats, Free Radic. Biol. Med., 47, 1067-1074.","journal-title":"Free Radic. Biol. Med."},{"key":"2064_CR21","doi-asserted-by":"publisher","first-page":"e66570","DOI":"10.1371\/journal.pone.0066570","volume":"8","author":"R. Meli","year":"2013","unstructured":"Meli, R., MattaceRaso, G., Irace, C., Simeoli, R., Di Pascale, A., Paciello, O., Pagano, T. B., Calignano, A., Colonna, A., and Santamaria, R. (2013) High fat diet induces liver steatosis and early dysregulation of iron metabolism in rats, PLoS One, 8, e66570.","journal-title":"PLoS One"},{"key":"2064_CR22","unstructured":"Pevzner, M. I. (1958) Principles of Dietotherapy (Acharkyan, A. I., and Marshak, M. S., eds.) Medgiz, Moscow (in Russian)."},{"key":"2064_CR23","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.crvi.2019.04.003","volume":"342","author":"O. Sihali-Beloui","year":"2019","unstructured":"Sihali-Beloui, O., Aroune, D., Benazouz, F., Hadji, A., El-Aoufi, S., and Marco, S. A. (2019) A hypercaloric diet induces hepatic oxidative stress, infiltration of lymphocytes, and mitochondrial reshuffle in Psammomys obesus, a murine model of insulin resistance, C R Biol., 342, 209-219, doi:\nhttps:\/\/doi.org\/10.1016\/j.crvi.2019.04.003\n.","journal-title":"C R Biol."}],"container-title":["Biochemistry (Moscow)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S0006297920090084.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1134\/S0006297920090084","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S0006297920090084.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:10:19Z","timestamp":1773619819000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1134\/S0006297920090084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["2064"],"URL":"https:\/\/doi.org\/10.1134\/s0006297920090084","relation":{},"ISSN":["0006-2979","1608-3040"],"issn-type":[{"value":"0006-2979","type":"print"},{"value":"1608-3040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"7 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interests. All applicable international, national and\/or institutional principles for the care and use of animals were followed.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declarations"}}]}}