{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:31:55Z","timestamp":1778859115467,"version":"3.51.4"},"reference-count":29,"publisher":"Pleiades Publishing Ltd","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochemistry Moscow"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1134\/s0006297924604489","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T04:41:05Z","timestamp":1748493665000},"page":"534-543","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling Oncogenic Power of WAVE1 in Bladder Cancer Progression"],"prefix":"10.1134","volume":"90","author":[{"given":"Shouxi","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"137","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"2853_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57080749","volume":"57","author":"J. Dobruch","year":"2021","unstructured":"Dobruch, J., and Oszczudlowski, M. (2021) Bladder cancer: current challenges and future directions, Medicina, 57, 749, \nhttps:\/\/doi.org\/10.3390\/medicina57080749.","journal-title":"Medicina"},{"key":"2853_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.100938","volume":"68","author":"F. Li","year":"2023","unstructured":"Li, F., Zheng, Z., Chen, W., Li, D., Zhang, H., Zhu, Y., Mo, Q., Zhao, X., Fan, Q., Deng, F., Han, C., and Tan, W. (2023) Regulation of cisplatin resistance in bladder cancer by epigenetic mechanisms, Drug Resist. Upd., 68, 100938, \nhttps:\/\/doi.org\/10.1016\/j.drup.2023.100938.","journal-title":"Drug Resist. Upd."},{"key":"2853_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110393","volume":"129","author":"J. Han","year":"2020","unstructured":"Han, J., Gu, X., Li, Y., and Wu, Q. (2020) Mechanisms of BCG in the treatment of bladder cancer \u2013 current understanding and the prospect, Biomed. Pharmacother., 129, 110393, \nhttps:\/\/doi.org\/10.1016\/j.biopha.2020.110393.","journal-title":"Biomed. Pharmacother."},{"key":"2853_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30972","volume":"71","author":"S. Basu","year":"2024","unstructured":"Basu, S., Rikhi, R., Arora, K., Joshi, V., Sharma, S., Rawat, A., Singh, S., and Suri, D. (2024) Wiskott-Aldrich syndrome protein expression in female WAS carriers: a flow cytometry study from North India, Pediatric Blood Cancer, 71, e30972, \nhttps:\/\/doi.org\/10.1002\/pbc.30972.","journal-title":"Pediatric Blood Cancer"},{"key":"2853_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9091217","volume":"9","author":"P. S. Rana","year":"2021","unstructured":"Rana, P. S., Alkrekshi, A., Wang, W., Markovic, V., and Sossey-Alaoui, K. (2021) The role of WAVE2 signaling in cancer, Biomedicines, 9, 1217, \nhttps:\/\/doi.org\/10.3390\/biomedicines9091217.","journal-title":"Biomedicines"},{"key":"2853_CR6","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005198","volume":"7","author":"S. Fried","year":"2014","unstructured":"Fried, S., Reicher, B., Pauker, M. H., Eliyahu, S., Matalon, O., Noy, E., Chill, J., and Barda-Saad, M. (2014) Triple-color FRET analysis reveals conformational changes in the WIP-WASp actin-regulating complex, Science signaling, 7, ra60, \nhttps:\/\/doi.org\/10.1126\/scisignal.2005198.","journal-title":"Science signaling"},{"key":"2853_CR7","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1073\/pnas.042686099","volume":"99","author":"J. Zhang","year":"2002","unstructured":"Zhang, J., Shi, F., Badour, K., Deng, Y., McGavin, M. K., and Siminovitch, K. A. (2002) WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development, Proc. Natl. Acad. Sci. USA, 99, 2240-2245, \nhttps:\/\/doi.org\/10.1073\/pnas.042686099.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2853_CR8","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.ygyno.2013.05.005","volume":"130","author":"J. Zhang","year":"2013","unstructured":"Zhang, J., Zhou, S., Tang, L., Shen, L., Xiao, L., Duan, Z., Jia, L., Cao, Y., and Mu, X. (2013) WAVE1 gene silencing via RNA interference reduces ovarian cancer cell invasion, migration and proliferation, Gynecol. Oncol., 130, 354-361, \nhttps:\/\/doi.org\/10.1016\/j.ygyno.2013.05.005.","journal-title":"Gynecol. Oncol."},{"key":"2853_CR9","doi-asserted-by":"publisher","first-page":"12383","DOI":"10.18632\/oncotarget.3564","volume":"6","author":"A. G. Sowalsky","year":"2015","unstructured":"Sowalsky, A. G., Sager, R., Schaefer, R. J., Bratslavsky, G., Pandolfi, P. P., Balk, S. P., and Kotula, L. (2015) Loss of Wave1 gene defines a subtype of lethal prostate cancer, Oncotarget, 6, 12383-12391, \nhttps:\/\/doi.org\/10.18632\/oncotarget.3564.","journal-title":"Oncotarget"},{"key":"2853_CR10","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.pathol.2020.11.003","volume":"53","author":"J. Cheng","year":"2021","unstructured":"Cheng, J., Song, Y., Xu, J., Li, H. H., and Zheng, J. F. (2021) LncRNA PVT1 promotes the malignant progression of acute myeloid leukaemia via sponging miR-29 family to increase WAVE1 expression, Pathology, 53, 613-622, \nhttps:\/\/doi.org\/10.1016\/j.pathol.2020.11.003.","journal-title":"Pathology"},{"key":"2853_CR11","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1126\/science.1240376","volume":"341","author":"K. Miyamoto","year":"2013","unstructured":"Miyamoto, K., Teperek, M., Yusa, K., Allen, G. E., Bradshaw, C. R., and Gurdon, J. B. (2013) Nuclear Wave1 is required for reprogramming transcription in oocytes and for normal development, Science, 341, 1002-1005, \nhttps:\/\/doi.org\/10.1126\/science.1240376.","journal-title":"Science"},{"key":"2853_CR12","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.omtn.2021.05.014","volume":"25","author":"S. Zhou","year":"2021","unstructured":"Zhou, S., Shen, Y., Zang, S., Yin, X., and Li, P. (2021) The epigenetic role of HTR1A antagonist in facilitaing GnRH expression for pubertal initiation control, Mol. Ther. Nucleic acids, 25, 198-206, \nhttps:\/\/doi.org\/10.1016\/j.omtn.2021.05.014.","journal-title":"Mol. Ther. Nucleic acids"},{"key":"2853_CR13","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/s13577-022-00815-0","volume":"36","author":"Y. Hu","year":"2023","unstructured":"Hu, Y., Shen, Y., Zhao, Y., Tang, Y., Liu, C., Gu, Y., Yang, T., and Shen, Y. (2023) Genomic distribution of signal transducer and activator of transcription (STAT) family in colorectal cancer, Hum. Cell, 36, 286-295, \nhttps:\/\/doi.org\/10.1007\/s13577-022-00815-0.","journal-title":"Hum. Cell"},{"key":"2853_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04818-5","volume":"13","author":"H. Song","year":"2022","unstructured":"Song, H., Tian, D., Sun, J., Mao, X., Kong, W., Xu, D., Ji, Y., Qiu, B., Zhan, M., and Wang, J. (2022) circFAM120B functions as a tumor suppressor in esophageal squamous cell carcinoma via the miR-661\/PPM1L axis and the PKR\/p38 MAPK\/EMT pathway, Cell Death Dis., 13, 361, \nhttps:\/\/doi.org\/10.1038\/s41419-022-04818-5.","journal-title":"Cell Death Dis."},{"key":"2853_CR15","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/cgt.2014.52","volume":"21","author":"Z. Yue","year":"2014","unstructured":"Yue, Z., Feng, W., Xiangke, L., Liuxing, W., Qingxia, F., and Jianbo, G. (2014) WAVE3 promotes epithelial-mesenchymal transition of gastric cancer through upregulation of Snail, Cancer Gene Ther., 21, 499-506, \nhttps:\/\/doi.org\/10.1038\/cgt.2014.52.","journal-title":"Cancer Gene Ther."},{"key":"2853_CR16","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/j.juro.2008.06.004","volume":"180","author":"H. S. Fernando","year":"2008","unstructured":"Fernando, H. S., Sanders, A. J., Kynaston, H. G., and Jiang, W. G. (2008) WAVE1 is associated with invasiveness and growth of prostate cancer cells, J.\u00a0Urol., 180, 1515-1521, \nhttps:\/\/doi.org\/10.1016\/j.juro.2008.06.004.","journal-title":"J.\u00a0Urol."},{"key":"2853_CR17","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nrm3758","volume":"15","author":"S. Lamouille","year":"2014","unstructured":"Lamouille, S., Xu, J., and Derynck, R. (2014) Molecular mechanisms of epithelial-mesenchymal transition, Nat. Rev. Mol. Cell Biol., 15, 178-196, \nhttps:\/\/doi.org\/10.1038\/nrm3758.","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2853_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00441-021-03574-w","volume":"388","author":"F. Oghbaei","year":"2022","unstructured":"Oghbaei, F., Zarezadeh, R., Jafari-Gharabaghlou, D., Ranjbar, M., Nouri, M., Fattahi, A., and Imakawa, K. (2022) Epithelial-mesenchymal transition process during embryo implantation, Cell Tissue Res., 388, 1-17, \nhttps:\/\/doi.org\/10.1007\/s00441-021-03574-w.","journal-title":"Cell Tissue Res."},{"key":"2853_CR19","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","volume":"20","author":"A. Dongre","year":"2019","unstructured":"Dongre, A., and Weinberg, R. A. (2019) New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer, Nat. Rev. Mol. Cell Biol., 20, 69-84, \nhttps:\/\/doi.org\/10.1038\/s41580-018-0080-4.","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2853_CR20","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s11684-018-0656-6","volume":"12","author":"Y. Zhang","year":"2018","unstructured":"Zhang, Y., and Weinberg, R. A. (2018) Epithelial-to-mesenchymal transition in cancer: complexity and opportunities, Front. Med., 12, 361-373, \nhttps:\/\/doi.org\/10.1007\/s11684-018-0656-6.","journal-title":"Front. Med."},{"key":"2853_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42628-1","volume":"14","author":"C. Kong","year":"2023","unstructured":"Kong, C., Qu, X., Liu, M., Xu, W., Chen, D., Zhang, Y., Zhang, S., Zhu, F., Liu, Z., Li, J., Huang, C., and Wang, C. (2023) Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance, Nat. Commun., 14, 6860, \nhttps:\/\/doi.org\/10.1038\/s41467-023-42628-1.","journal-title":"Nat. Commun."},{"key":"2853_CR22","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/ncb3478","volume":"19","author":"A. Labernadie","year":"2017","unstructured":"Labernadie, A., Kato, T., Brugues, A., Serra-Picamal, X., Derzsi, S., Arwert, E., Weston, A., Gonzalez-Tarrago, V., Elosegui-Artola, A., Albertazzi, L., Alcaraz, J., Roca-Cusachs, P., Sahai, E., and Trepat, X. (2017) A mechanically active heterotypic E-cadherin\/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion, Nat. Cell Biol., 19, 224-237, \nhttps:\/\/doi.org\/10.1038\/ncb3478.","journal-title":"Nat. Cell Biol."},{"key":"2853_CR23","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1101\/gad.349358.122","volume":"36","author":"K. M. Ridge","year":"2022","unstructured":"Ridge, K. M., Eriksson, J. E., Pekny, M., and Goldman, R. D. (2022) Roles of vimentin in health and disease, Genes & Dev., 36, 391-407, \nhttps:\/\/doi.org\/10.1101\/gad.349358.122.","journal-title":"Genes & Dev."},{"key":"2853_CR24","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022111252","volume":"42","author":"T. Cremer","year":"2023","unstructured":"Cremer, T., Voortman, L. M., Bos, E., Jongsma, M. L., Ter Haar, L. R., Akkermans, J. J., Talavera Ormeno, C. M., Wijdeven, R. H., de Vries, J., Kim, R. Q., Janssen, G. M., van Veelen, P. A., Koning, R. I., Neefjes, J., and Berlin, I. (2023) RNF26 binds perinuclear vimentin filaments to integrate ER and endolysosomal responses to proteotoxic stress, EMBO\u00a0J., 42, e111252, \nhttps:\/\/doi.org\/10.15252\/embj.2022111252.","journal-title":"EMBO\u00a0J."},{"key":"2853_CR25","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2174\/15680096113136660102","volume":"13","author":"Y. Wang","year":"2013","unstructured":"Wang, Y., Shi, J., Chai, K., Ying, X., and Zhou, B. P. (2013) The role of snail in EMT and tumorigenesis, Curr. Cancer Drug Targets, 13, 963-972, \nhttps:\/\/doi.org\/10.2174\/15680096113136660102.","journal-title":"Curr. Cancer Drug Targets"},{"key":"2853_CR26","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/onc.2016.227","volume":"36","author":"G. Cai","year":"2017","unstructured":"Cai, G., Wu, D., Wang, Z., Xu, Z., Wong, K. B., Ng, C. F., Chan, F. L., and Yu, S. (2017) Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial-mesenchymal transition and remodeling of actin cytoskeleton organization, Oncogene, 36, 546-558, \nhttps:\/\/doi.org\/10.1038\/onc.2016.227.","journal-title":"Oncogene"},{"key":"2853_CR27","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1007\/s10620-016-4102-9","volume":"61","author":"Z. Zhu","year":"2016","unstructured":"Zhu, Z., Chen, W., Yin, X., Lai, J., Wang, Q., Liang, L., Wang, W., Wang, A., and Zheng, C. (2016) WAVE3 Induces EMT and promotes migration and invasion in intrahepatic cholangiocarcinoma, Digest. Dis. Sci., 61, 1950-1960, \nhttps:\/\/doi.org\/10.1007\/s10620-016-4102-9.","journal-title":"Digest. Dis. Sci."},{"key":"2853_CR28","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3892\/ijo.2018.4421","volume":"53","author":"S. Huang","year":"2018","unstructured":"Huang, S., Huang, C., Chen, W., Liu, Y., Yin, X., Lai, J., Liang, L., Wang, Q., Wang, A., and Zheng, C. (2018) WAVE3 promotes proliferation, migration and invasion via the AKT pathway in pancreatic cancer, Int.\u00a0J. Oncol., 53, 672-684, \nhttps:\/\/doi.org\/10.3892\/ijo.2018.4421.","journal-title":"Int.\u00a0J. Oncol."},{"key":"2853_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.743682","volume":"12","author":"Q. Zhu","year":"2021","unstructured":"Zhu, Q., Li, K., Li, H., Han, F., Tang, Z., and Wang, Z. (2021) Ketamine induced bladder fibrosis through MTDH\/P38 MAPK\/EMT pathway, Front. Pharmacol., 12, 743682, \nhttps:\/\/doi.org\/10.3389\/fphar.2021.743682.","journal-title":"Front. Pharmacol."}],"container-title":["Biochemistry (Moscow)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S0006297924604489.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1134\/S0006297924604489","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S0006297924604489.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:22:01Z","timestamp":1773620521000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1134\/S0006297924604489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["2853"],"URL":"https:\/\/doi.org\/10.1134\/s0006297924604489","relation":{},"ISSN":["0006-2979","1608-3040"],"issn-type":[{"value":"0006-2979","type":"print"},{"value":"1608-3040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"10 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethics approval and consent to participate.\n                      All procedures were in accordance with the Helsinki Declaration. The protocol of the current study was approved by the Ethics Committee of Changzhou Cancer Hospital (no.\u00a02024-006) and with the Helsinki Declaration of 1975, as revised in 2013. Informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declarations"}},{"value":"Conflict of interest.\n                      The authors of this work declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declarations"}}]}}