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A new compound ethyl-2-(4-(4-(5-amino-6-(\n                      <jats:italic>tert<\/jats:italic>\n                      -butylcarbamoyl)-2-(methylthio)thieno[2,3-d]-pyrimidine-4-yl)phenyl)-\n                      <jats:italic>1H<\/jats:italic>\n                      -1,2,3-triazol-1-yl) acetate (TPY3m), which stimulated the production of thyroxine when administered to rats (25\u00a0mg\/kg, i.p.) and also increased the expression of thyroidogenic genes in the cultured FRTL-5 thyrocytes (30 \u03bcM) and the rat thyroid gland. The in vitro and in vivo treatment with TPY3m did not lead to a decrease in the expression of the TSH receptor gene in thyrocytes, restoring it under the conditions of receptor hyperactivation by the hormone. This determines the retaining and, in some cases, potentiation of the thyroidogenic effects of TSH (FRTL-5) or thyroliberin (rats) when they are coadministered with TPY3m. TPY3m is a prototype drug for correcting thyroid system functions in subclinical hypothyroidism.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1134\/s1607672922020016","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T18:02:24Z","timestamp":1652205744000},"page":"67-70","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Development of Low-Molecular-Weight Allosteric Agonist of Thyroid-Stimulating Hormone Receptor with Thyroidogenic Activity"],"prefix":"10.1134","volume":"503","author":[{"given":"A. A.","family":"Bakhtyukov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. V.","family":"Derkach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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The authors declare that they have no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"COMPLIANCE WITH ETHICAL STANDARDS"}},{"value":"Statement on the welfare of animals\n                      . When working with animals, the requirements of the Bioethics Committee of the Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences (protocol no. 9\u20131\/2020), the Guidelines for the Care and Use of Laboratory Animals, and Directive 2010\/63\/EU of the European Parliament and the Council of the EU were observed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"COMPLIANCE WITH ETHICAL STANDARDS"}}]}}