{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:36:53Z","timestamp":1773772613457,"version":"3.50.1"},"reference-count":19,"publisher":"Pleiades Publishing Ltd","issue":"1","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dokl Biochem Biophys"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Preeclampsia (PE) is one of the most dangerous complications of pregnancy, characterized by hypertension, proteinuria, and symptoms of multiple organ failure, which are detected de novo after 20 weeks of pregnancy. The renin\u2013angiotensin\u2013aldosterone system (RAAS) is one of the first to recognize pregnancy and is an important regulator of blood pressure. The placenta has its own RAAS, the role of which in the development of PE is not fully understood. In this work, for the first time, we characterized the expression of RAAS components and miRNAs controlling it in the placenta at various times of PE manifestation. The data obtained will allow the development of a new strategy in the future for the search for therapeutic agents for patients suffering from PE and cardiovascular diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1134\/s1607672922060011","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T11:04:13Z","timestamp":1672311853000},"page":"256-263","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia"],"prefix":"10.1134","volume":"507","author":[{"given":"K. A.","family":"Artemieva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. V.","family":"Nizyaeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. R.","family":"Baev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Yu.","family":"Romanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. V.","family":"Khlestova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. N.","family":"Boltovskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. I.","family":"Shchegolev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. V.","family":"Kakturskiy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"137","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"7332_CR1","doi-asserted-by":"crossref","unstructured":"Aneman, I., Pienaar, D., Suvakov, S., et al., Mechanisms of key innate immune cells in early- and late-onset preeclampsia, Front. Immunol., 2020, vol. 11, no.\u00a01864.","DOI":"10.3389\/fimmu.2020.01864"},{"key":"7332_CR2","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1177\/1753944715597622","volume":"9","author":"I.R.C. Barbosa","year":"2015","unstructured":"Barbosa, I.R.C., Silva, W.B.M., Cerqueira, G.S.G., et\u00a0al., Maternal and fetal outcome in women with hypertensive disorders of pregnancy: the impact of prenatal care, Ther. Adv. Cardiovasc. Dis., 2015, vol. 9, pp.\u00a0140\u2013146.","journal-title":"Ther. Adv. Cardiovasc. 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The authors declare that they have no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"COMPLIANCE WITH ETHICAL STANDARDS"}},{"value":"Statement of compliance with standards of research involving humans as subjects\n                      . The work was approved by the Ethics Committee of the Kulakov National Research Center for Obstetrics, Gynecology, and Perinatology of the Ministry of Health of Russia, Protocol no. 6 dated June 9, 2016. All patients signed voluntary informed consent to participate in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"COMPLIANCE WITH ETHICAL STANDARDS"}}]}}