{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:37:55Z","timestamp":1773772675259,"version":"3.50.1"},"reference-count":20,"publisher":"Pleiades Publishing Ltd","issue":"1","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dokl Biochem Biophys"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1134\/s1607672923700448","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T15:01:35Z","timestamp":1702479695000},"page":"274-278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In HIV-Infected Immunological Non-Responders, Hepatitis C Virus Eradication Contributes to Incomplete Normalization of Systemic Inflammation Indexes, but Does Not Lead to Rapid CD4+ T-Cell Count Recovery"],"prefix":"10.1134","volume":"512","author":[{"given":"E. V.","family":"Saidakova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. B.","family":"Korolevskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. G.","family":"Shmagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. V.","family":"Vlasova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Yu.","family":"Shardina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. A.","family":"Chereshnev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. V.","family":"Shmagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"137","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"7430_CR1","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1097\/QAD.0000000000001203","volume":"30","author":"K.W. Chew","year":"2016","unstructured":"Chew, K.W. and Bhattacharya, D., Virologic and immunologic aspects of HIV\u2013hepatitis C virus coinfection, AIDS, 2016, vol. 30, no. 16, pp. 2395\u20132404.","journal-title":"AIDS"},{"key":"7430_CR2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1097\/QAD.0000000000002040","volume":"33","author":"D.K. van Santen","year":"2019","unstructured":"van Santen, D.K., van der Helm, J.J., Touloumi, G., et\u00a0al., Effect of incident hepatitis C infection on CD4+ cell count and HIV RNA trajectories based on a multinational HIV seroconversion cohort, AIDS, 2019, vol.\u00a033, no. 2, pp. 327\u2013337.","journal-title":"AIDS"},{"key":"7430_CR3","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/QAI.0000000000002157","volume":"82","author":"R. Rb-Silva","year":"2019","unstructured":"Rb-Silva, R., Goios, A., Kelly, C., et al., Definition of immunological nonresponse to antiretroviral therapy: a systematic review, J. Acquired Immune Defic. Syndr., 2019, vol. 82, no. 5, pp. 452\u2013461.","journal-title":"J. Acquired Immune Defic. Syndr"},{"key":"7430_CR4","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/JLB.4MR1019-189R","volume":"107","author":"X. Yang","year":"2020","unstructured":"Yang, X., Su, B., Zhang, X., et al., Incomplete immune reconstitution in HIV\/AIDS patients on antiretroviral therapy: challenges of immunological non-responders, J. Leukoc. Biol., 2020, vol. 107, no. 4, pp. 597\u2013612.","journal-title":"J. Leukoc. Biol"},{"key":"7430_CR5","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/cmi.2016.3","volume":"13","author":"M.W. Robinson","year":"2016","unstructured":"Robinson, M.W., Harmon, C., and O\u2019Farrelly, C., Liver immunology and its role in inflammation and homeostasis, Cell Mol. Immunol., 2016, vol. 13, no. 3, pp.\u00a0267\u2013276.","journal-title":"Cell Mol. Immunol"},{"key":"7430_CR6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1134\/S0012496617030024","volume":"474","author":"E.V. Saidakova","year":"2017","unstructured":"Saidakova, E.V., Shmagel, K.V., Korolevskaya, L.B., et\u00a0al., (CD8+) T cell expansion in HIV\/HCV coinfection is associated with systemic inflammation, Dokl. Biol. Sci., 2017, vol. 474, no. 1, pp. 126\u2013128.","journal-title":"Dokl. Biol. Sci"},{"key":"7430_CR7","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1053\/j.gastro.2006.09.052","volume":"131","author":"T. Marcello","year":"2006","unstructured":"Marcello, T., Grakoui, A., Barba-Spaeth, G., et al., Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics, Gastroenterology, 2006, vol. 131, no.\u00a06, pp. 1887\u20131898.","journal-title":"Gastroenterology"},{"key":"7430_CR8","doi-asserted-by":"publisher","first-page":"30079","DOI":"10.1074\/jbc.M804296200","volume":"283","author":"N.E. Pagliaccetti","year":"2008","unstructured":"Pagliaccetti, N.E., Eduardo, R., Kleinstein, S.H., et al., Interleukin-29 functions cooperatively with interferon to induce antiviral gene expression and inhibit hepatitis C virus replication, J. Biol. Chem., 2008, vol.\u00a0283, no. 44, pp. 30079\u201330089.","journal-title":"J. Biol. Chem"},{"key":"7430_CR9","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/gene.2009.72","volume":"10","author":"K. Witte","year":"2009","unstructured":"Witte, K., Gruetz, G., Volk, H.D., et al., Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines, Genes Immun., 2009, vol. 10, no. 8, pp. 702\u2013714.","journal-title":"Genes Immun"},{"key":"7430_CR10","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.ejca.2009.10.002","volume":"46","author":"Q. Li","year":"2010","unstructured":"Li, Q., Kawamura, K., Ma, G., et al., Interferon-lambda induces G1 phase arrest or apoptosis in oesophageal carcinoma cells and produces anti-tumour effects in combination with anti-cancer agents, Eur. J. Cancer, 2010, vol. 46, no. 1, pp. 180\u2013190.","journal-title":"Eur. J. Cancer"},{"key":"7430_CR11","doi-asserted-by":"publisher","first-page":"7686","DOI":"10.4049\/jimmunol.176.12.7686","volume":"176","author":"A. Sato","year":"2006","unstructured":"Sato, A., Ohtsuki, M., Hata, M., et al., Antitumor activity of IFN-lambda in murine tumor models, J. Immunol., 2006, vol. 176, no. 12, pp. 7686\u20137694.","journal-title":"J. Immunol"},{"key":"7430_CR12","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1016\/j.bbrc.2006.04.043","volume":"344","author":"K. Zitzmann","year":"2006","unstructured":"Zitzmann, K., Brand, S., Baehs, S., et al., Novel interferon-lambdas induce antiproliferative effects in neuroendocrine tumor cells, Biochem. Biophys. Res. Commun., 2006, vol. 344, no. 4, pp. 1334\u20131341.","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"7430_CR13","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.3390\/ijms231911936","volume":"23","author":"P. Zuccala","year":"2022","unstructured":"Zuccala, P., Latronico, T., Marocco, R., et al., Longitudinal assessment of multiple immunological and inflammatory parameters during successful DAA therapy in HCV monoinfected and HIV\/HCV coinfected subjects, Int. J. Mol. Sci., 2022, vol. 23, no. 19, pp. 1193\u20131213.","journal-title":"Int. J. Mol. Sci"},{"key":"7430_CR14","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1093\/infdis\/jiw457","volume":"214","author":"J. Hengst","year":"2016","unstructured":"Hengst, J., Falk, C.S., Schlaphoff, V., et al., Direct-acting antiviral-induced hepatitis C virus clearance does not completely restore the altered cytokine and chemokine milieu in patients with chronic hepatitis C, J. Infect. Dis., 2016, vol. 214, no. 12, pp. 1965\u20131974.","journal-title":"J. Infect. Dis"},{"key":"7430_CR15","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1080\/00365521.2018.1481996","volume":"53","author":"L.T. Lund","year":"2018","unstructured":"Lund, L.T., Brockner, S.C., Kazankov, K., et al., Rapid and persistent decline in soluble CD163 with successful direct-acting antiviral therapy and associations with chronic hepatitis C histology, Scand. J. Gastroenterol., 2018, vol. 53, no. 8, pp. 986\u2013993.","journal-title":"Scand. J. Gastroenterol"},{"key":"7430_CR16","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1053\/j.gastro.2015.03.004","volume":"149","author":"E. Serti","year":"2015","unstructured":"Serti, E., Chepa-Lotrea, X., Kim, Y.J., et al., Successful interferon-free therapy of chronic hepatitis C virus infection normalizes natural killer cell function, Gastroenterology, 2015, vol. 149, no. 1, pp. 190\u2013200.","journal-title":"Gastroenterology"},{"key":"7430_CR17","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.1172\/JCI75938","volume":"124","author":"E.G. Meissner","year":"2014","unstructured":"Meissner, E.G., Wu, D., Osinusi, A., et al., Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome, J. Clin. Invest., 2014, vol. 124, no. 8, pp. 3352\u20133363.","journal-title":"J. Clin. Invest"},{"key":"7430_CR18","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1002\/hep4.1074","volume":"1","author":"E.G. Meissner","year":"2017","unstructured":"Meissner, E.G., Kohli, A., Higgins, J., et al., Rapid changes in peripheral lymphocyte concentrations during interferon-free treatment of chronic hepatitis C virus infection, Hepatol. Commun., 2017, vol. 1, no. 7, pp. 586\u2013594.","journal-title":"Hepatol. Commun"},{"key":"7430_CR19","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.3390\/diagnostics11122336","volume":"11","author":"A. Marino","year":"2021","unstructured":"Marino, A., Zafarana, G., Ceccarelli, M., et al., Immunological and clinical impact of DAA-mediated HCV eradication in a cohort of HIV\/HCV coinfected patients: monocentric italian experience, Diagnostics (Basel), 2021, vol. 11, no. 12, pp. 2336\u20132250.","journal-title":"Diagnostics"},{"key":"7430_CR20","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1111\/jvh.13488","volume":"28","author":"A. Bandera","year":"2021","unstructured":"Bandera, A., Lorenzini, P., Taramasso, L., et al., The impact of DAA-mediated HCV eradication on CD4+ and CD8+ T lymphocyte trajectories in HIV\/HCV coinfected patients: Data from the ICONA Foundation Cohort, J. Viral Hepat., 2021, vol. 28, no. 5, pp. 779\u2013786.","journal-title":"J. Viral Hepat"}],"container-title":["Doklady Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672923700448.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1134\/S1607672923700448","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1134\/S1607672923700448.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:21:01Z","timestamp":1773760861000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1134\/S1607672923700448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["7430"],"URL":"https:\/\/doi.org\/10.1134\/s1607672923700448","relation":{},"ISSN":["1607-6729","1608-3091"],"issn-type":[{"value":"1607-6729","type":"print"},{"value":"1608-3091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"20 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Conflict of interest\n                      . The authors declare that they have no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"COMPLIANCE WITH ETHICAL STANDARDS"}},{"value":"Statement of compliance with standards of research involving humans as subjects\n                      . The work plan was approved by the Ethics Committee of the Perm Regional Center for Combating AIDS and Infectious Diseases (committee registration no. IRB00008964), protocol No. 31 dated March 3, 2017. Informed consent was obtained from each participant.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"COMPLIANCE WITH ETHICAL STANDARDS"}}]}}